Search for dissertations about: "Patrik Ståhl"

Showing result 1 - 5 of 8 swedish dissertations containing the words Patrik Ståhl.

  2. 1. Methods for Analyzing Genomes

    Author : Patrik L. Ståhl; Joakim Lundeberg; Ivo Gut; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; array; sequence capture; genotyping; trinucleotide threading; sequencing; massively parallel sequencing; single molecule sequencing; Visual DNA; p53; single nucleotide polymorphism; biomarker; Genetics; Genetik;

    Abstract : The human genome reference sequence has given us a two‐dimensional blueprint of our inherited code of life, but we need to employ modern‐day technology to expand our knowledge into a third dimension. Inter‐individual and intra‐individual variation has been shown to be larger than anticipated, and the mode of genetic regulation more complex. READ MORE

  4. 2. Spatially Resolved Gene Expression Analysis

    Author : Michaela Asp; Joakim Lundeberg; Patrik Ståhl; Thierry Voet; KTH; []
    Keywords : RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; Bioteknologi; Biotechnology;

    Abstract : Spatially resolved transcriptomics has greatly expanded our knowledge of complex multicellular biological systems. To date, several technologies have been developed that combine gene expression data with information about its spatial tissue context. READ MORE

  5. 3. Spatial Tissue Mapping on Joint Biopsies from Arthritis Patients

    Author : Konstantin Carlberg; Patrik Ståhl; Vivianne Malmström; Anna-Karin Hultgård Ekwall; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune prediction; Rheumatoid arthritis; Spatial RIN; Spatial Transcriptomics; Spondyloarthritis; Bioteknologi; Biotechnology;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that mainly affects joints, causing discomfort and pain that severely reduces the life quality of affected individuals. Its etiology is largely unknown, but some pathophysiological mechanisms have been identified. READ MORE

  6. 4. Mosaic loss of chromosome Y : methods for detection and consequences for affected leukocytes and men

    Author : Marcus Danielsson; Lars A. Forsberg; Ståhl Patrik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mosaic loss of chromosome Y; mLOY; somatic mosaicism; Medicinsk genetik; Medical Genetics;

    Abstract : It has been known for centuries that men live shorter lives than women, but until recently, the biological mechanisms driving this sex bias has been poorly understood. Mosaic loss of chromosome Y (mLOY) refers to chromosome Y aneuploidy, a male specific and the most common somatic mutation in human blood cells. READ MORE

  7. 5. Intracellular systems for characterization and engineering of proteases and their substrates

    Author : George Kostallas; Stefan Ståhl; Patrik Samuelson; Matthew DeLisa; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; proteases; flow cytometry; GFP; CAT; protein engineering; ssrA; ClpXP; tobacco etch virus; TEV; site-specific; high-throughput; selection; proteolysis; libraries; Bioengineering; Bioteknik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Abstract : Over the years, the view on proteases as relatively non-specific protein degradation enzymes, mainly involved in food digestion and intracellular protein turnover, has shifted and they are now recognized as key regulators of many biological processes that determine the fate of a cell. Besides their biological role, proteases have emerged as important tools in various biotechnical, industrial and medical applications. READ MORE