Search for dissertations about: "Pdyn"

Showing result 1 - 5 of 9 swedish dissertations containing the word Pdyn.

2. 1. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain

   Author : Bejan Aresh; Malin Lagerström; Klas Kullander; Martin Schmelz; Uppsala universitet; []
   Keywords : mGluR7; anaphylaxis; Grpr; Penk; Pdyn; Cre line; BAC cloning; spinal cord; transgenic line; Medicinsk vetenskap; Medical Science;

   Abstract : We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) population that are involved at different levels of itch transmission. We found that mGuR7 deficient mice displayed an anaphylaxis-like behavior when provoked with histamine. READ MORE

4. 2. Molecular mechanisms underlying increased PDYN and dynorphin expression in the prefrontal cortex of alcoholic men

   Author : Richard Henriksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alcohol dependence is a chronic relapsing disorder caused by drug x gene x environment interactions for which pharmacotherapy is but moderately effective. The prefrontal cortex is a brain region important for cognitive control / behavioral flexibility which function is impaired in alcoholics. READ MORE

5. 3. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

   Author : Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

   Abstract : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. READ MORE

6. 4. Mechanisms of Prodynorphin Gene Dysregulation in the Brain of Human Alcoholics

   Author : Malik Mumtaz Taqi; Georgy Bakalkin; Fred Nyberg; Hallberg Mathias; Wolfgang.H Sommer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : The endogenous opioid system (EOS) including dynorphin opioid peptides and κ-opioid receptor (KOR) plays a critical role in alcohol dependence. Aims of the thesis were to evaluate whether the EOS undergoes molecular adaptations in brain areas involved in cognitive control of addiction in human alcohol dependent subjects, and to analyze the impact of genetic and epigenetic factors on these adaptive changes. READ MORE

7. 5. Opioid and non-opioid activities of the dynorphins

   Author : Zoya Marinova; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN). Dynorphins regulate pain processing and memory acquisition and modulate reward induced by intake of addictive substances. READ MORE