Search for dissertations about: "Pediatric glioma"
Showing result 1 - 5 of 11 swedish dissertations containing the words Pediatric glioma.
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1. Heparan Sulfate Proteoglycans in Brain Tumor Development
Abstract : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. READ MORE
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2. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools
Abstract : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. READ MORE
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3. Deciphering microglia plasticity in glioma
Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE
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4. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications
Abstract : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. READ MORE
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5. Modeling and investigations of high-grade glioma to understand tumorigenesis and heterogeneity
Abstract : Glioblastoma (GBM) is the most common primary malignant brain tumor. As per 2021 WHO classification, the corresponding diagnosis in children is called diffuse pediatric-type high-grade glioma (pHGG). In both cases tumors are histone 3 (H3) and isocitrate dehydrogenase 1/2 (IDH1/2) wildtype (wt). READ MORE