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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Fibroblast Growth Factor Receptor-1 Function in Vasculo- and Angiogenesis

    Author : Peetra Magnusson; Lena Claesson-Welsh; Anne Eichmann; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR-1; VEGFR-2; PDGFR-β; endothelial cells; embryonic stem cell; angiogenesis; hematopoiesis; Patologi; Pathology; Patologi;

    Abstract : During development of the mammalian embryo, spatial and temporal expression of fibroblast growth factors (FGFs) and their cognate receptors are vital in the regulation of a number of patterning processes. Inappropriate or decreased expression leads to severe malformations and even embryonic death. READ MORE

  4. 2. Pancreatic Islet Transplantation : Modifications of Islet Properties to Improve Graft Survival

    Author : Sanja Cabric; Olle Korsgren; Bo Nilsson; Peetra Magnusson; Michael Breimer; Uppsala universitet; []
    Keywords : Medicine; Diabetes; islet transplantation; islets of Langerhans; coagulation activation; IBMIR; hirudin; heparin; growth factor; angiogenesis; Medicin;

    Abstract : During the past decade clinical islet transplantation has become a viable strategy for curing type 1 diabetes. The limited supply of organs, together with the requirement for islets from multiple donors to achieve insulin independence, has greatly limited the application of this approach. READ MORE

  5. 3. Strategies in Cochlear Nerve Regeneration, Guidance and Protection : Prospects for Future Cochlear Implants

    Author : Fredrik Edin; Helge Rask-Andersen; Peetra Magnusson; Maoli Duan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human vestibular nerve; Scarpa s ganglion; Stem cells; Nanoparticles; Nanocrystalline diamond; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Science; Medicinsk vetenskap;

    Abstract : Today, it is possible to restore hearing in congenitally deaf children and severely hearing-impaired adults through cochlear implants (CIs). A CI consists of an external sound processor that provides acoustically induced signals to an internal receiver. READ MORE

  6. 4. Inflammation and immunothrombosis in cerebral cavernous malformation : Novel molecular targets for the treatment of an incurable disease

    Author : Maria Ascención Globisch; Peetra Magnusson; Elisabetta Dejana; Marie Jeansson; Anna Randi; Uppsala universitet; []
    Keywords : Cavernoma; Inflammation; Coagulation; Blood-brain-barrier; Blood; Hypoxia; Propranolol; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology;

    Abstract : Cerebral cavernous malformation (CCM) is a vascular disease that causes mulberry-like lesions (cavernomas) in the central nervous system (CNS). Cavernomas are fragile, leaky and prone to rupture which may cause symptoms such as epileptic seizures, focal neurological deficits and hemorrhagic strokes. CCM lesions can appear sporadically in 0. READ MORE

  7. 5. Neutrophil extracellular traps as potential therapeutic targets to prevent tumor-induced organ failure and metastasis

    Author : Melanie Herre; Anna-Karin Olsson; Jessica Cedervall; Peetra Magnusson; Benoit Ho-Tin-Noé; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophil extracellular traps; NETs; cancer; metastasis; inflammation; organ dysfunction; thrombosis; Oncology; Onkologi;

    Abstract : Cancer does not only affect surrounding tissues, but also leads to complications at distant sites. The reason for this is that tumors secrete factors and prime cells that travel through the body, making cancer a systemic disease. In fact, cancer death is mostly caused by systemic complications such as metastasis, organ failure or thrombosis. READ MORE