Search for dissertations about: "Peptide array"

Showing result 1 - 5 of 41 swedish dissertations containing the words Peptide array.

  2. 1. Characterization of antibody specificity using peptide array technologies

    Author : Björn Forsström; Mathias Uhlén; Markus Templin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody; Epitope mapping; Peptide array; Suspension bead array; Antigen; Specificity; Cross-reactivity; Immunization; Immunogenicity; Bioteknologi; Biotechnology;

    Abstract : Antibodies play an important role in the natural immune response to invading pathogens. The strong and specific binding to their antigens also make them indispensable tools for research, diagnostics and therapy. READ MORE

  4. 2. Array-based Autoantibody Profiling and Epitope Mapping

    Author : Arash Zandian; Peter Nilsson; Jochen M. Schwenk; Maja Neiman; Morten Nielsen; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; antibody; antigens; peptide; epitope mapping; autoimmunity; autoantibodies; microarrays; Bioteknologi; Biotechnology;

    Abstract : Antibodies are a class of proteins that are made by the immune system to recognize harmful organisms and molecules. Their exceptional capability of specifically recognizing molecules has been investigated for over a century and information thereof has been utilized for a variety of applications including vaccine and generation of therapeutic antibodies. READ MORE

  5. 3. Characterising Halogen Bonding in a Cooperative Model System

    Author : Stefan Peintner; Mate Erdelyi; Anja Sandström; Uppsala universitet; []
    Keywords : Halogen Bond; NMR; peptide; conformation; RDC; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Abstract : Non-covalent interactions are the main driving factor for secondary structure formation of biomacromolecules and are of enormous importance for the direction of molecular recognition events, for example those of importance for drug discovery. Profound understanding of these interactions is of vital importance to achieve high affinity and selectivity of a ligand to a chosen target. READ MORE

  6. 4. Epitope mapping of antibodies towards human protein targets

    Author : Barbara Hjelm; Mathias Uhlén; Larry Gold; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antibody; antibody validation; biomarker; epitope mapping; peptide array; proteomics; RBM3; staphylococcal surface display;

    Abstract : This thesis, based on five research papers, presents results from development and evaluation ofmethods for identifying the interaction site of antibodies on their antigens and the functional investigation of these in different assays. As antibodies have proven to be invaluable tools in diagnostics, therapy and basic research, the demand of characterizing these binding molecules has increased. READ MORE

  7. 5. Innate immunity atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide

    Author : Kristina Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Atherosclerosis; innate immunity; inflammation; Toll-like receptor; nucleotide oligomerization domain protein; antimicrobial peptide;

    Abstract : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. READ MORE