Search for dissertations about: "Peptide bond formation"

Showing result 1 - 5 of 29 swedish dissertations containing the words Peptide bond formation.

  1. 1. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Masoud Kazemi; Uppsala universitet.; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE

  2. 2. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mikhail Savitski; Uppsala universitet.; [2007]
    Keywords : Bioinformatics; Proteomics; Peptide fragmentation; Bioinformatik;

    Abstract : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. READ MORE

  3. 3. An Investigation of Peroxidase Activity in Biomimetic and Biological Systems

    University dissertation from Inorganic Chemistry, Chemical Center, Lund University

    Author : Ekaterina Ryabova; Lunds universitet.; Lund University.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolism; Metabolism; enzymologi; Proteiner; enzymology; Proteins; hemoglobin; catalysis; peptide; peroxidase; protoporphyrin IX; Biokemi; Biochemistry;

    Abstract : Popular Abstract in Swedish Järn är den mest vanligt förekommande övergångsmetallen i alla levande organismer, från bakterier till växter och djur och även i människan. Järn är en viktig del av olika proteiner och förekommer mycket ofta i form av en hemgrupp (se bild). Enzymer är proteiner som kan katalysera biokemiska processer. READ MORE

  4. 4. Molecular mechanisms and complete antigen formation in allergic contact dermatitis

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Stefan Ahlfors; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypersensitivity; adduct; immune response.; Allergy; hapten;

    Abstract : Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. READ MORE

  5. 5. Computer simulations of ribosome reactions

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Stefan Trobro; Uppsala universitet.; [2008]
    Keywords : Molecular biology; ribosomal termination; Empirical valence bond; peptidyl transfer; Molekylärbiologi;

    Abstract : Peptide bond formation and translational termination on the ribosome have been simulated by molecular mechanics, free energy perturbation, empirical valence bond (MD/FEP/EVB) and automated docking methods. Recent X-ray crystallographic data is used here to calculate the entire free energy surface for the system complete with substrates, ribosomal groups, solvent molecules and ions. READ MORE