Search for dissertations about: "Peptide bond formation"

Showing result 21 - 25 of 33 swedish dissertations containing the words Peptide bond formation.

  2. 21. Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation

    Author : Martin J Mueller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotriene (LT) A4 hydrolase catalyzes the committed step in the biosynthesis of LTB4, a classical chemoattractant and immuine-modulating lipid mediator involved in inflammation, host-defense against infections, and systemic, PAF-mediated, lethal shock. LTA4 hydrolase is a bifunctional zinc metalloenzyme with a chloride stimulated arginyl aminopeptidase activity. READ MORE

  4. 22. Antiplasmin the main plasmin inhibitor in blood plasma : studies on structure-function relationships

    Author : Haiyao Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Antiplasmin; lysine-binding-site; inactivation;

    Abstract : Antiplasmin is an important regulator of the fibrinolytic system. It inactivates plasmin very rapidly. The reaction between plasmin and antiplasmin occurs in several steps: first a lysine-binding site in plasmin interacts with a complementary site in antiplasmin. READ MORE

  5. 23. The eukaryotic ribosome in focus : a chemical footprinting analysis of ribosome-ligand interactions in in vivo assembled complexes

    Author : Marika Salonen Sloma; Diarmaid Hughes; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi; Zoological Cell Biology; zoologisk cellbiologi;

    Abstract : Protein synthesis is an essential biological process that occurs on ribosomes. The process requires an involvement of numerous components like mRNA, tRNA and translation factors. The mammalian 80S ribosome, the focus of this thesis, is composed of four rRNAs and approximately 80 proteins distributed in two subunits the 40S and 60S subunit. READ MORE

  6. 24. Ribosomal proteins L5 and L15 : Functional characterisation of important features, in vivo

    Author : Ivailo Simoff; Odd Nygård; Gustavo Nader; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; cellbiologi; Cellbiology;

    Abstract : Protein synthesis is a highly regulated and energy consuming process, during which a large ribonucleoprotein particle called the ribosome, synthesizes new proteins. The eukaryotic ribosome consists of two unequal subunits called: small and large subunits. Both subunits are composed of ribosomal RNA (rRNA) and ribosomal proteins (r-proteins). READ MORE

  7. 25. Identification of the domains of disulfide interaction in the mammalian ribosomal proteins L6 and L29

    Author : Heinz Nika; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The 60-S subunits of mammalian ribosomes contain two adjacent proteins, identified as L6 and L29, which interact reversibly in situ by disulfide bond formation. The disulfide complex and the individual proteins were prepared by polyacrylamide gel electrophoresis under non-oxidizing conditions for effective prevention of methionine oxidation. READ MORE