Search for dissertations about: "Peptide toxin"

Showing result 1 - 5 of 35 swedish dissertations containing the words Peptide toxin.

  2. 1. Novel RelA-SpoT Homolog toxin-antitoxin systems that inhibit bacterial growth through production of toxic alarmone ppApp

    Author : Steffi Jimmy; Vasili Hauryliuk; Vicky Shingler; Michael T. Laub; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; p ppGpp; ppApp; toxin; antitoxin; alarmone; antibacterials; molekylärbiologi; Molecular Biology; Biochemistry; biokemi;

    Abstract : The stress alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively known as (p)ppGpp, are the molecular mediators of the bacterial stringent response — a bacterial stress response implicated in virulence, antibiotic tolerance and biofilm formation. At high concentrations, (p)ppGpp halts bacterial growth, inhibits protein synthesis and rewires transcription and metabolism. READ MORE

  4. 2. Antibody- and Peptide-based Immunotherapies : Proof-of-concept and safety considerations

    Author : Erika Fletcher; Sara Mangsbo; Vivianne Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immune complex; conjugat; vaccine; CD40; whole blood; cytokine release syndrome; Immunologi; Immunology;

    Abstract : The aim of cancer immunotherapy is to eradicate tumours by inducing a tumour-specific immune response. This thesis focuses on how antibodies and peptides can improve antigen presentation and the subsequent tumour-specific T cell response. Tumour recognition by the immune system can be promoted through delivery of antigen in the form of a vaccine. READ MORE

  5. 3. Studies on cysteine-rich peptides from Nemertea and Violaceae : Proteomic and transcriptomic discovery and characterization

    Author : Erik Jacobsson; Ulf Göransson; Håkan S. Andersson; Robert Burman; Espen Hansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide toxin; cystine knot; nemertide; cyclotide; nemertea.; Farmakognosi; Pharmacognosy;

    Abstract : The overall aims of the projects included in this thesis were to discover, synthesize and characterize disulphide-stabilized peptides from marine worms (Nemertea sp.) and plants (Viola sp.). READ MORE

  6. 4. Studies of the pathogenesis of Shiga toxin-producing Escherichia coli-induced hemolytic uremic syndrome

    Author : Ida Arvidsson; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; hemolytic uremic syndrome; Shiga toxin; complement; hemolysis; microvesicles; cathelicidin;

    Abstract : Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia and acute kidney failure. The most common form of HUS is associated with gastrointestinal Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) infection. EHEC are non-invasive strains with Shiga toxin as the unique virulence factor. READ MORE

  7. 5. Activation of professional phagocytes with emphasis on the formyl peptide receptor family

    Author : Jennie Karlsson; Göteborgs universitet; []
    Keywords : phagocyte; G-protein coupled receptor; chemoattractant; formyl peptide receptor; reactive oxygen species; calcium;

    Abstract : Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more specifically chemoattractant receptors are a vital part in guiding phagocytes towards the site of infection. READ MORE