Search for dissertations about: "Peptide"

Showing result 11 - 15 of 1714 swedish dissertations containing the word Peptide.

  2. 11. Intracellular and peptide interactions of C-peptide

    Author : Emma Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proinsulin C-peptide is depleted together with insulin in type I diabetic patients. The supplement of insulin to these patients is necessary for their survival, but it is also likely that the loss of C-peptide may contribute to both short- and long-term complications. In this thesis, molecular effects of C-peptide have been investigated. READ MORE

  4. 12. The endocrine heart - metabolic actions of atrial natriuretic peptide

    Author : Amra Jujic; Kardiovaskulär forskning - hypertoni; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrial natriuretic peptide; type 2 diabetes; rs5068; insulin resistance; glucose dependent insulinotropic peptide; glucagon-like peptide-1; left ventricular hypertrophy;

    Abstract : Abstract The natriuretic peptides (NPs), namely atrial natriuretic peptide (ANP) and bran natriuretic peptide (BNP), which are secreted from cardiomyocytes in response to cardiac wall stress, play a significant role in the regulation of blood pressure, intravascular volume, and cardiac remodeling. Recently, NPs emerged as hormones with metabolic actions such as inhibition of the renin-angiotensin system and inhibition of inflammation, together with lipolysis and adipose tissue browning. READ MORE

  5. 13. Interaction Between Antimicrobial Peptides and Phospholipid Membranes : Effects of Peptide Length and Composition

    Author : Lovisa Ringstad; Martin Malmsten; Per Hansson; Jeremy Ramsden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adsorption; antibacterial; antimicrobial peptide; bilayer; ellipsometry; electrochemistry; electrostatic interactions; hydrophobicity; liposome; membrane; monolayer; phospholipid; secondary structure; supported bilayer.; PHARMACY; FARMACI; Pharmaceutical Physical Chemistry; farmaceutisk fysikalisk kemi;

    Abstract : Due to increasing problems with bacterial resistance development, there is a growing need for identifying new types of antibiotics. Antimicrobial peptides constitute an interesting group of substances for this purpose, since they are believed to act mainly by disrupting the bacterial membrane, which is a fast and non-specific mechanism. READ MORE

  6. 14. Conformational Studies of Biologically Active Peptides

    Author : Björn Walse; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PapD chaperone; P pili; desmopressin; DDAVP; protein-peptide interactions; glycopeptides; peptide design; transferred NOE; molecular dynamics simulations; circular dichroism; peptide conformation; NMR spectroscopy; immunogenic glycopeptides; Physical chemistry; Fysikalisk kemi;

    Abstract : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. READ MORE

  7. 15. Polymeric Nanoparticles as Carriers for Antimicrobial Peptides : Factors Affecting Peptide and Membrane Interactions

    Author : Randi Nordström; Martin Malmsten; Per Hansson; Helena Bysell; Erica Wanless; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; antimicrobial peptide; microgel; degradable; nanogel; drug delivery; PEGylation; secondary structure; model membrane; lipid bilayer; neutron reflectometry; ellipsometry; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

    Abstract : As resistance towards conventional antibiotics is becoming more pronounced, cationic antimicrobial peptides (AMPs) have received considerable attention as possible therapeutic alternatives. Thousands of potent AMPs occur in humans, animals, plants and fungi as a natural part of the immune system. READ MORE