Search for dissertations about: "Perfusion process"
Showing result 1 - 5 of 57 swedish dissertations containing the words Perfusion process.
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1. Tools for the development of intensified perfusion processes for mammalian cell culture
Abstract : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. READ MORE
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2. Hydrodynamics considerations in cells systems from ocean flow to perfusion cultivation process
Abstract : Microorganisms and animal cells are grown surrounded by fluid, which is providing them with nutrients and removing their waste products. In nature and industry processes, cells/microbes can be subject to aggressive environments, such as turbulent flow or shear flow. READ MORE
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3. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells
Abstract : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. READ MORE
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4. Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics
Abstract : The mismatching of alveolar ventilation and perfusion (VA/Q) is the major determinant of impaired gas exchange. The gold standard for analyzing VA/Q distribution is the multiple inert gas elimination technique (MIGET), conventionally based on gas chromatography (GC), and, although simple in principle, a technically demanding procedure limiting its use. READ MORE
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5. Quantification of pulmonary scintigraphy
Abstract : Modern nuclear medicine techniques, such as SPECT (single photon emission computed tomography), enable quantification and localisation of lung function in small lung elements, but appropriate methods are not yet available. The aim of the present project was therefore to develop and evaluate methods for mapping lung function in planar scintigrams and in SPECT. READ MORE