Search for dissertations about: "Periplasmic binding protein"

Showing result 11 - 15 of 19 swedish dissertations containing the words Periplasmic binding protein.

  2. 11. Expression of a lipase in prokaryote and eukaryote host systems allowing engineering

    Author : Marianne Wittrup Larsen; Karl Hult; Marina Lotti; KTH; []
    Keywords : pseudozzyma candida antarctica lipase B; escherichia coli; pichia pastoris; rational design;

    Abstract : Pseudozyma (Candida) antarctica lipase B (PalB) was expressed in Escherichia coli facilitating protein engineering. The lack of glycosylation was evaluated for a deeper understanding of the difficulties in expressing PalB in E. coli. READ MORE

  4. 12. NMR as a tool in drug research : Structure elucidation of peptidomimetics and pilicide-chaperone complexes

    Author : Mattias Hedenström; Jan Jan Kihlberg; Ingmar Sethson; Michael P. Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; NMR; structure calculations; peptidomimetics; desmopressin; Leu-enkephalin; chemical shift mapping; pilicides; chaperones; urinary tract infections.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in the pharmaceutical industry. This thesis describes applications of NMR spectroscopy in biomedicinal research for structure elucidation of biologically active peptides and peptidomimetics as well as in studies of ligand-protein interactions. READ MORE

  5. 13. Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition

    Author : Eva Maria Rebrova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. READ MORE

  6. 14. Structural studies of enzymes regulating bacterial life style and cell wall biogenesis

    Author : Ming Wei Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bacteria can adapt to different biotic and abiotic environments by changing their life style, switching between sessile or motile, free-living or community-bound, virulent or dormant states. Each bacterium also faces the challenges of maintaining a protective barrier while growing, replicating and responding to environmental changes. READ MORE

  7. 15. Chaperone/usher machinery : a catalyst of virulence organelle assembly

    Author : Xiaodi Yu; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Many virulence organelles of Gram-negative bacterial pathogens are assembled via the periplasmic chaperone/usher (CU) pathway. The assembly process is a complex task, involving secretion of organelle subunits via the two membranes and periplasm, subunit folding and assembly. READ MORE