Search for dissertations about: "Permeabilization"

Showing result 11 - 15 of 37 swedish dissertations containing the word Permeabilization.

  2. 11. Regulation of human cell viability by the host defence peptide LL-37

    Author : Daniel Svensson; Kärlfysiologi; []
    Keywords : LL-37; cathelicidin; cytotoxicity; host defence peptides; autoimmune diseases; inflammation; vitamin D;

    Abstract : Accumulating evidence suggests that the main human cathelicidin peptide, LL-37, may influence host cell viability and pro-inflammatory signaling when locally overexpressed. LL-37 has pro-inflammatory properties linked to the development of for example psoriasis, rosacea, SLE and atherosclerosis. READ MORE

  4. 12. Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease

    Author : Lin Zheng; Jan Marcusson; Alexei Terman; Martin Hallbeck; Lars Nilsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD), the major cause of senile dementia, is associated with progressive formation of neurofibrillary tangles and extraneuronal plaques composed of amyloid beta peptide (Aβ). Aβ has been also found within Alzheimer neurons in association with the lysosomal system, an acidic vacuolar compartment possessing numerous hydrolytic enzymes. READ MORE

  5. 13. The role of the mitochondrial membrane system in apoptosis : the influence of oxidative stress on membranes and their interactions with apoptosis-regulating Bcl-2 proteins

    Author : Martin Lidman; Gerhard Gröbner; Magnus Wolf-Watz; Philip Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bax; Bc-2; apoptosis; mitochondria; membranes; oxidized lipids; NMR; calorimetry; circular dichroism; biokemi; Biochemistry; fysikalisk kemi; Physical Chemistry;

    Abstract : Apoptosis is a crucial process in multicellular organisms in sculpting them, especially during embryogenesis. In addition, apoptosis is responsible for the clearance of harmful or damaged cells which can otherwise be detrimental to the organism. READ MORE

  6. 14. Mitochondrial involvement in cell death : release of pro-apoptotic proteins

    Author : Erik Norberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In addition to the role of the mitochondria in energy metabolism, these organelles play a key role in cell death signaling. In particular, mitochondrial alterations, such as stimulation of reactive oxygen species (ROS) formation, decreased ATP synthesis, loss of membrane potential and the release of pro-apoptotic proteins from the mitochondrial intermembrane space (IMS), have been shown to be involved in, and often responsible for, various manifestations of cell death. READ MORE

  7. 15. Mitochondria : a target for anticancer therapy

    Author : Björn Kruspig; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority of cancers demonstrate aberrations in mitochondrial functions, which were shown to contribute to tumourigenesis. READ MORE