Search for dissertations about: "Peter Hackman"

Found 1 swedish dissertation containing the words Peter Hackman.

2. 1. HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients

   Author : Peter Hackman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Somatic gene mutation; mutational spectra; HPRT gene; lung cancer; smoking; hMLH1 gene; HNPCC; microsatellite instability; mismatch repair; T-cells;

   Abstract : The, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. READ MORE