Search for dissertations about: "Ph chromosome"

Showing result 1 - 5 of 21 swedish dissertations containing the words Ph chromosome.

  2. 1. Genetic Sex Differences in Early Human Neuronal Development : An Investigation in Embryo Tissue and Embryonic Stem Cells

    Author : Philipp Pottmeier; Elena Jazin; Armin Raznahan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex chromosome; gametolog; x y homolog; male; female; sex differences; sex bias; embryonic stem cells; neurodevelopment; neuronal differentiation; neural stem cells; genetics; neurodevelopmental disorders; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Neuroscience; Neurovetenskap; Medicinsk genetik; Medical Genetics;

    Abstract : Sex differences in the human body affect many different organs and tissues, some of them have an effect on the human brain and its development. In the developing nervous system, sex differences can bias the number or functionality of neurons, glial cells or synapses. As a result, neural networks might develop with a sex-specific bias. READ MORE

  4. 2. Analysis of Nucleotide Variations in Non-human Primates

    Author : Ann-Charlotte Rönn; Ann-Christine Syvänen; Mats Nilsson; Phillip Morin; Uppsala universitet; []
    Keywords : Molecular genetics; SNP; genotyping; primate; chimpanzee; whole genome amplification; multiple displacement amplification; minisequencing; microarray; Y-chromosome; mitochondria; Genetik;

    Abstract : Many of our closest relatives, the primates, are endangered and could be extinct in a near future. To increase the knowledge of non-human primate genomes, and at the same time acquire information on our own genomic evolution, studies using high-throughput technologies are applied, which raises the demand for large amounts of high quality DNA. READ MORE

  5. 3. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer

    Author : Cynthia Veenstra; Olle Stål; Gizeh Perez-Tenorio; Pietras Kristian; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. READ MORE

  6. 4. Modelling the evolution of treatment-induced resistance in Ph+ leukaemias

    Author : Jonathan Lindström; Ran Friedman; Arne Traulsen; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic myeloid leukaemia; Stochastic modelling; Tyrosine kinase inhibitor; Drug resistance; Clonal evolution; Biomedical Sciences; Biomedicinsk vetenskap; Medicinsk kemi; Medical Chemistry;

    Abstract : Targeted therapies are a mainstay of modern cancer treatments. Rather than harming rapidly dividing cells in general, targeted therapies work by directly interfering with oncogenic molecular pathways present in a tumour. Consequently, a targeted therapy typically has less severe side effects. READ MORE

  7. 5. Molecular and functional studies of the BCR/ABL1 fusion gene

    Author : Petra Johnels; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; onkologi; Cytologi; cancerology; oncology; Cytology; gene expression profiling; acute lymphoblastic leukemia; chronic myeloid leukemia; Ph chromosome; BCR ABL; extracellulära vätskor; Clinical genetics; Klinisk genetik; cancer;

    Abstract : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. READ MORE