Search for dissertations about: "Pharmaceutical Science"

Showing result 1 - 5 of 140 swedish dissertations containing the words Pharmaceutical Science.

  1. 1. Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

    Author : Annika Borde; [2012]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sublingual vaccine tablet; freeze-drying; mucosal vaccination; osmotic pressure; Vibrio cholerae; hydrophilic matrix tablets; Bradford Assay; protein release; mucoadhesion;

    Abstract : Most vaccines today are liquid formulations for parental administration. However, there are several drawbacks connected to these vaccines. Since injectable vaccines only induce systemic antibody responses, they are not effective against the various pathogens that affect mucosal surfaces with poor permeability for serum-derived antibodies, e.g. READ MORE

  2. 2. Pharmaceutical Nanocomposites Structure–Mobility–Functionality Relationships in the Amorphous State

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joel Hellrup; Uppsala universitet.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous; pharmaceutical composites; solid state; structure; molecular mobility; spray-drying; freeze-drying; moisture sorption; physical stability; compression; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. READ MORE

  3. 3. Process-induced disorder of pharmaceutical materials Mechanisms and quantification of disorder

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Samaneh Pazesh; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milling; Comminution; Powder flow; Amorphisation; Raman spectroscopy; Atomic force microscopy; Plastic stiffness; Elastic stiffness; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : One of the most important prerequisites in the drug development is to attain a reproducible and robust product in terms of its nature, and its chemical and physical properties. This can be challenging, since the crystalline form of drugs and excipients can be directly transformed into the amorphous one during normal pharmaceutical processing, referred to as process-induced amorphisation or process-induced disorder. READ MORE

  4. 4. Application of Artificial Gel Antibodies for the Detection and Quantification of Proteins in Biological Fluids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nasim Ghasemzadeh; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The molecular-imprinting method has previously been used for the synthesis of artificial gel antibodies, highly selective for various proteins. In present study, we have synthesized artificial gel antibodies against haemoglobin, albumin and different forms of growth hormone with the aim to develop a simple and rapid procedure to measure the concentration of these protein biomarkers in samples of clinical interest. READ MORE

  5. 5. Pharmaceutical cocrystals formation mechanisms, solubility behaviour and solid-state properties

    University dissertation from Luleå : Luleå tekniska universitet

    Author : Amjad Alhalaweh; Luleå tekniska universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocrystal; formation; solubility; pH; dissolution; surface properties; Pharmaceutics; Pharmacy; Farmaci; Health Science; Hälsovetenskap;

    Abstract : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. READ MORE