Search for dissertations about: "Pharmaceutical polymorphs"

Found 3 swedish dissertations containing the words Pharmaceutical polymorphs.

  2. 1. Preparation of Pharmaceutical Powders using Supercritical Fluid Technology : Pharmaceutical Applications and Physicochemical Characterisation of Powders

    Author : Sitaram Velaga; Johan Carlfors; Kristiina Järvinen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Supercritical fluid; Gas Anti-Solvent; SEDS; Crystallisation; Particle design; Polymorphs; Dry powder inhalation; Solid-state behaviour; Therapeutic proteins; Precipitation; Stability; Recombinant human growth hormone hGH ; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The main aim of the thesis was to explore the potential of supercritical fluid (SF) techniques in the field of drug delivery. In particular, the relatively recently developed solution-enhanced dispersion by supercritical fluids (SEDS) technology has been employed in the preparation of particles/powders. READ MORE

  4. 2. Investigating polymorphism in small molecules using three-dimensional electron diffraction

    Author : Molly Lightowler; Xiaodong Zou; Hosea M. Nelson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 3D electron diffraction; structure determination; polymorphism; crystallisation; phase identification; small molecule; oorganisk kemi; Inorganic Chemistry;

    Abstract : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. READ MORE

  5. 3. Crystalline Porous Materials Inspired by Metallodrugs

    Author : Erik Svensson Grape; A. Ken Inge; Tomislav Friščić; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metal-organic frameworks; material synthesis; pharmaceuticals; porous materials; crystallography; oorganisk kemi; Inorganic Chemistry;

    Abstract : Inspiration for developing robust porous materials from sustainable reagents was acquired by determining the crystal structures of bismuth subsalicylate and bibrocathol, two long-used and commonly available bismuth-based pharmaceuticals. From these insights, a number of coordination polymers and metal-organic frameworks (MOFs) were developed, facilitating the synthesis of robust porous materials from sustainably sourced reagents. READ MORE