Search for dissertations about: "Pharmaceutical processes"

Showing result 1 - 5 of 167 swedish dissertations containing the words Pharmaceutical processes.

  2. 1. The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene : Connecting Transcriptional and Posttranscriptional Processes

    Author : Tina Glisovic; Matti Lang; Francoise Raffalli-Mathieu; Lorenz Poellinger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; Cyp2a5; DNA-protein interaction; gene regulation; hnRNP A1; nucleocytoplasmic shuttling; RNA-protein interaction; RNA stabilization; posttranscriptional; transcriptional; Farmaceutisk biokemi; Pharmaceutical biochemistry; Farmaceutisk biokemi;

    Abstract : The mouse xenobiotic-inducible Cyp2a5 gene is both transcriptionally and posttranscriptionally regulated. One of the most potent Cyp2a5 inducers, the hepatotoxin pyrazole, increases the CYP2A5 mRNA half-life. READ MORE

  4. 2. Preparation of Pharmaceutical Powders using Supercritical Fluid Technology : Pharmaceutical Applications and Physicochemical Characterisation of Powders

    Author : Sitaram Velaga; Johan Carlfors; Kristiina Järvinen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Supercritical fluid; Gas Anti-Solvent; SEDS; Crystallisation; Particle design; Polymorphs; Dry powder inhalation; Solid-state behaviour; Therapeutic proteins; Precipitation; Stability; Recombinant human growth hormone hGH ; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The main aim of the thesis was to explore the potential of supercritical fluid (SF) techniques in the field of drug delivery. In particular, the relatively recently developed solution-enhanced dispersion by supercritical fluids (SEDS) technology has been employed in the preparation of particles/powders. READ MORE

  5. 3. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

    Author : Amjad Alhalaweh; Peter York; Luleå tekniska universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; crystal engineering; cocrystal; formation; solubility; pH; dissolution; surface properties; solid-state properties; Health Science; Hälsovetenskap;

    Abstract : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. READ MORE

  6. 4. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Author : Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. READ MORE

  7. 5. The Impact of Substance P (SP) N-Terminal Metabolite SP1-7 in Opioid Tolerance and Withdrawal

    Author : Qin Zhou; Tsukasa Sakurada; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The heptapeptide SP1-7, a metabolite of the neuroactive peptide substance P (SP), is suggested to play a role in opioid addiction and memory function. These two dimensions are known to involve dopamine and glutamate transmissions mediated through dopamine receptors and N-methyl-D- aspartate (NNMA) receptors, respectively. READ MORE