Search for dissertations about: "Pharmaceutics"
Showing result 1 - 5 of 66 swedish dissertations containing the word Pharmaceutics.
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1. Mechanical strength of pharmaceutical compacts : Importance of material characteristics, particle characteristics and compaction pressure on interparticulate bonding structure
Abstract : Factors considered important for the interparticulate bonding structure and mechanical strength of pharmaceutical compacts were studied in this thesis.Fractures appear to propagate mainly around rather than through grains during strength testing. READ MORE
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2. In vitro and in silico prediction of drug-drug interactions with transport proteins
Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE
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3. Oral delivery of macromolecules formulated with permeation enhancers
Abstract : Therapeutic macromolecules including peptides, proteins, and nucleotide-based ones (such as antisense oligonucleotides and RNAs) have great potential as drug candidates. One drawback is that they typically need to be administered parenterally via subcutaneous, intramuscular or intravenous injections. READ MORE
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4. Engineering of Pharmaceutical Particles : Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process
Abstract : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. READ MORE
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5. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption
Abstract : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. READ MORE
