Search for dissertations about: "Pharmaceutics"

Showing result 1 - 5 of 61 swedish dissertations containing the word Pharmaceutics.

  1. 1. In vitro and in silico prediction of drug-drug interactions with transport proteins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gustav Ahlin; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

    Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE

  2. 2. Engineering of Pharmaceutical Particles Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Berggren; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; particle engineering; microcrystalline cellulose pellets; intragranular porosity; convective drying; tabletting behaviour; spray-dried composite particles; amorphous lactose; PVP; heat and moisture-induced crystallisation; glass transition temperature; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. READ MORE

  3. 3. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christel A. S. Bergström; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; aqueous drug solubility; melting point; intestinal drug permeability; pH-dependent solubility; multivariate data analysis; molecular descriptors; molecular surface area; in silico modeling; drug absorption; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci;

    Abstract : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. READ MORE

  4. 4. New Concepts in Administration of Drugs in Tablet Form Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Susanne Bredenberg; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Interactive mixture; Dose homogeneity; Disintegration; Bioadhesion; Oromucosal delivery; Sublingual tablet; Rapid absorption; Individual dosage; Drug dispensing device; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. READ MORE

  5. 5. Catanionic Aggregates in Gels Prolonged Drug Release and Potential Implications for Topical Use

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Noel Dew; Uppsala universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Galenisk farmaci; Pharmaceutics;

    Abstract : Gels are popular dosage forms.  This topical dosage form may be advantageous compared to oral or parenteral dosage forms. Favorable rheological or bioadhesive properties of gels might provide extended contact times at the site of administration compared to aqueous solutions. READ MORE