Search for dissertations about: "Pharmaceutics"

Showing result 21 - 25 of 66 swedish dissertations containing the word Pharmaceutics.

  2. 21. Transport and metabolism of opioid tetrapeptide agonists with a focus on oral and respiratory delivery

    Author : Eva Krondahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; opioid peptides; permeability; metabolism; oral delivery; pulmonary delivery; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The clinical development of peptide drugs for oral delivery has often been hindered because of poor transport across the intestinal membranes and degradation in the gastrointestinal tract and liver. Alternative delivery routes through more permeable membranes preferably with less pronounced proteolytic activity, such as the nasal and pulmonary routes, have therefore been considered. READ MORE

  4. 22. Chitosan Polyplexes as Non-Viral Gene Delivery Systems : Structure-Property Relationships and In Vivo Efficiency

    Author : Magnus Köping-Höggård; Per Artursson; Jean-Paul Behr; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gene therapy; gene delivery; non-viral; polyplex; chitosan; chitosan oligomers; polyethylenimine; plasmid DNA; lung; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The subject of this thesis was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biocompatible polymers, in particular chitosan, suitable for non-viral gene therapy. At the onset of this thesis, studies had reported conflicting results on the efficiency of chitosan-based gene delivery systems. READ MORE

  5. 23. Intestinal transport and hepatic extraction of fluvastatin in humans and rats

    Author : Anders Lindahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The oral route is the most convenient route of delivering drugs intended to have systemic effects. One of the key variables determining the rate and extent of absorption from the gastrointestinal tract is the intestinal permeability to the drug. READ MORE

  6. 24. Validation of Several Nucleoside Tracers as Proliferation Markers

    Author : Li Lu; Sven Reske; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; PET; cell proliferation; DNA synthesis; hydroxyurea; cimetidine; diuretic; Biofarmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. READ MORE

  7. 25. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

    Author : Pär Matsson; Per Artursson; Ulf Norinder; Peter Swaan; Uppsala universitet; []
    Keywords : Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

    Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE