Search for dissertations about: "Pharmacokinetic and Pharmacodynamic Models"
Showing result 1 - 5 of 36 swedish dissertations containing the words Pharmacokinetic and Pharmacodynamic Models.
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1. Development and Evaluation of Nonparametric Mixed Effects Models
Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE
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2. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling
Abstract : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. READ MORE
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3. Models for Ordered Categorical Pharmacodynamic Data
Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE
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4. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres
Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE
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5. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance
Abstract : Exposure to antibiotics is an important factor influencing the development of bacterial resistance. In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. READ MORE