Search for dissertations about: "Pharmacokinetics Pharmacotherapy"

Showing result 1 - 5 of 14 swedish dissertations containing the words Pharmacokinetics Pharmacotherapy.

  2. 1. Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport

    Author : Emma Boström; Margareta Hammarlund-Udenaes; Ulrika Simonsson; Danny D Shen; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; pharmacokinetics; pharamcodynamics; blood-brain barrier; oxycodone; microdialysis; NONMEM; brain distribution; transport; Farmakokinetik Farmakoterapi;

    Abstract : The pharmacokinetics and pharmacodynamics of oxycodone and morphine was investigated and related to the transport across the blood-brain barrier (BBB) in rats. The influence of a P-glycoprotein (P-gp) inhibitor on the plasma pharmacokinetics and pharmacodynamics of oxycodone was evaluated. READ MORE

  4. 2. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Author : Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

  5. 3. Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis

    Author : Doaa Elsherbiny; Ulrika Simonsson; Mats Karlsson; Lars Ståhle; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Drug-drug interactions; Cytochrome P-450; Artemisinin antimalarials; Nevirapine; Lopinavir; Rifampicin; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Malaria, Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are global health problems having their worst situation in sub-Saharan Africa. Consequently, concomitant use of antimalarial, antiretroviral and antitubercular drugs may be needed, resulting in a potential risk of drug-drug interactions. READ MORE

  6. 4. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime

    Author : Anders Viberg; Marie Sandström; Otto Cars; Mats Karlsson; Hartmut Derendorf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Cefuroxime; pharmacokinetics; pharmacodynamics; dosing individualisation; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. READ MORE

  7. 5. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel

    Author : Anja Henningsson; Mats O. Karlsson; Lena Friberg; Iñaki F. Trocóniz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Mechanism-based; Modelling; Myelosuppression; Paclitaxel; Cremophor EL; NONMEM; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE