Search for dissertations about: "Pharmacokinetics skin"

Showing result 1 - 5 of 12 swedish dissertations containing the words Pharmacokinetics skin.

  2. 1. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Author : Marie V Magnusson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Abstract : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). READ MORE

  4. 2. Assessment of microvascular function by use of transdermal iontophoresis : methodological aspects

    Author : Erik Droog Tesselaar; Folke Sjöberg; Angela Shore; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Iontophoresis; Microcirculation; Laser-Doppler; Acetylcholine; Sodium nitroprusside; Pharmacodynamics; Pharmacokinetics skin; Physiology and pharmacology; Fysiologi och farmakologi;

    Abstract : Assessment of the microcirculation is of major importance in understanding the physiology of the vasculature and in assessing te vascular effects of pathological conditions such as diabetes, hypertension and sepsis. Transdermal iontophoresis can be used to non‐invasively introduce vasoactive drugs into the skin. READ MORE

  5. 3. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance

    Author : Ingegerd Gustafsson; Otto Cars; Niels Frimodt-Möller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microbiology; Human microflora; antibiotic resistance; selection; mutation frequency; biological fitness; pharmacokinetics; pharmacodynamics; β-lactam antibiotics; suboptimal dosing regimen; Mikrobiologi; Microbiology; Mikrobiologi; Klinisk bakteriologi; Clinical Bacteriology;

    Abstract : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. READ MORE

  6. 4. Distribution of antiviral nucleoside analogues into brain and skin

    Author : Natalia Borg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. READ MORE

  7. 5. Optical spectroscopy in biomedicine - detection of embedded inclusions and in vivo pharmacokinetics

    Author : Jenny Svensson; Atomfysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; temperature; Atomic and molecular physics; Atom- och molekylärfysik; photosensitizer; photodynamic therapy; fluorescence spectroscopy; multispectral imaging;

    Abstract : The main theme of this thesis is the use of fluorescence spectroscopy in biomedicine. The work presented in the thesis can be divided into three areas of applications. The first area involves the use of fluorescence to find the location of a deeply situated fluorophore within turbid media. READ MORE