Search for dissertations about: "Pharmacology"

Showing result 1 - 5 of 880 swedish dissertations containing the word Pharmacology.

  1. 1. Pharmacology of Palmitoylethanolamide and Related Compounds

    University dissertation from Umeå : Farmakologi och klinisk neurovetenskap

    Author : Kent-Olov Jonsson; Umeå universitet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; anandamide; cannabinoid; FAAH; palmitoylethanolamide; palmitoylisopropylamide; inflammation; mast cells; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Anandamide (AEA) is an endogenous fatty acid which activates the same cannabinoid receptors as ∆9-tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts a number of actions including effects upon pain and inflammation. READ MORE

  2. 2. Cloning, Expression, Pharmacological Characterization and Anatomical Distribution of Melanocortin Receptors in an Evolutionary Perspective

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Aneta I. Ringholm; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; evolution; melanocortin; MSH; pharmacology; genome duplication; tetraploidization; zebrafish; spiny dogfish; chicken; GPCR; polymorphism; pigmentation; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : The melanocortin (MC) receptors are G-protein coupled receptors thatparticipate in several important physiological functions such as the regulation of the energy balance. This thesis focuses on the evolutionary aspect of the MC receptors and their pharmacology.One MC4 receptor and two MC5 receptor subtypes were found in a teleost fish, zebrafish. READ MORE

  3. 3. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joachim Gullbo; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; pharmacology; oncology; chemistry; Melphalan derivatives; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE

  4. 4. Development and Evaluation of Nonparametric Mixed Effects Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Paul Baverel; Uppsala universitet.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonparametric; model; pharmacometrics; pharmacokinetics; pharmacodynamic; imprecision; covariate analysis; parameter distribution; SOCIAL SCIENCES Statistics; computer and systems science; SAMHÄLLSVETENSKAP Statistik; data- och systemvetenskap; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Biopharmaceutics; Biofarmaci; Clinical Pharmacology; Klinisk farmakologi; Computer Systems; Datorteknik; Farmakologi; Pharmacology; Statistics; Statistik;

    Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE

  5. 5. Cellular Pharmacology of the Novel Antitumoural Cyanoguanidine CHS 828

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Henrik Lövborg; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; Cyanoguanidines; Oncology; Pharmacology; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : The antitumoural cyanoguanidine CHS 828 has shown promising activity in a number of preclinical and clinical studies. However, the mechanisms underlying the cell death induced by CHS 828 has not been clarified. This thesis describes in vitro studies of the cellular pharmacology of CHS 828. READ MORE