Search for dissertations about: "Pharmacology"

Showing result 11 - 15 of 396 swedish dissertations containing the word Pharmacology.

  2. 11. The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation

    Author : Lina Thors; Christopher J Fowler; David A Kendall; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocannabinoid; anandamide; cellular processing; pain; flavonoids; fatty acid amide hydrolase; Pharmacology; Farmakologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) exert most of their actions by binding to cannabinoid receptors. The effects of the endocannabinoids are short-lived due to rapid cellular accumulation and metabolism, for AEA, primarily by the enzymes fatty acid amide hydrolase (FAAH). READ MORE

  4. 12. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors

    Author : Bo Xu; Dan Larhammar; Samuel Svensson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuropeptide Y; genome duplication; Evolution; vertebrate; Pharmacology; Modelling; Kinetics; Bioinformatik; Bioinformatics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. READ MORE

  5. 13. Function, Pharmacology, Evolution and Anatomical Localization of G Protein-Coupled Receptors and Solute Carriers

    Author : Tatjana Haitina; Robert Fredriksson; Gert Flik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi; Medicine; medicin;

    Abstract : The G protein-coupled receptors (GPCRs) and solute carriers (SLC) are two large families of membrane-bound proteins. The aim of this study was to characterize these two families in terms of evolution and function. READ MORE

  6. 14. Benefits of Non-Linear Mixed Effect Modeling and Optimal Design : Pre-Clinical and Clinical Study Applications

    Author : Charles Ernest II; Andrew Hooker; Mats Karlsson; Bart Ploeger; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; optimal design; nonlinear mixed effects models; population models; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Despite the growing promise of pharmaceutical research, inferior experimentation or interpretation of data can inhibit breakthrough molecules from finding their way out of research institutions and reaching patients. This thesis provides evidence that better characterization of pre-clinical and clinical data can be accomplished using non-linear mixed effect modeling (NLMEM) and more effective experiments can be conducted using optimal design (OD). READ MORE

  7. 15. From Food Preference to Craving : Behavioural Traits and Molecular Mechanisms

    Author : Johan Alsiö; Helgi B Schiöth; Jonas Lindblom; Anna M Kindlundh-Högberg; Suzanne Dickson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; Reward; Food preferences; Dietary fats; Dietary carbohydrates; Anxiety; Dopamine; Craving; Operant self-administration; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Abstract : Preference for palatable and energy-dense foods may be a risk factor for body weight gain and has both genetic and environmental components. Once obesity develops in an individual, weight loss is difficult to achieve. READ MORE