Search for dissertations about: "Phd thesis in immunology"

Showing result 1 - 5 of 23 swedish dissertations containing the words Phd thesis in immunology.

  1. 1. Life and death of human B cells in health and disease

    Author : Andy Dernstedt; Mattias N. E. Forsell; Clas Ahlm; Jonas Klingström; Mats Bemark; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; b cells; antibody; hantavirus; germinal centre; phagocytosis; selection; DAF; vaccination; rituximab;

    Abstract : B cells provide one of the key mechanisms of immunological memory, which is theproduction of neutralising antibodies. How B cells respond to infections and vaccinationgives clues to how the development of the immunological memory is facilitated, and canthus lead to a deeper understanding of why the immune system sometimesmalfunctions. READ MORE

  2. 2. Glucocorticoid receptors in severe inflammation : Experimental and clinical studies

    Author : Maria Bergquist; Göran Hedenstierna; Christian Rylander; Catharina Lindholm; Cecile Martijn; Djillali Annane; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoid receptor; sepsis; inflammation; flow cytometry; Klinisk immunologi; Clinical Immunology;

    Abstract : Septic shock is one of the most common causes of mortality in intensive care, in spite of antibiotic treatment. Glucocorticoid treatment can be used to blunt an overwhelming immune response in severe inflammation. READ MORE

  3. 3. Myeloid-Derived Suppressor Cells and Other Immune Escape Mechanisms in Chronic Leukemia

    Author : Lisa Christiansson; Angelica S I Loskog; Ulla Olsson-Strömberg; Andreas Lundqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic myeloid leukemia; myeloid-derived suppressor cells; sCD25; tyrosine kinase inhibitors; multiplex protein quantification; Medical Science; Medicinsk vetenskap;

    Abstract : Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome, a minute chromosome that leads to the creation of the fusion gene BCR/ABL and the transcription of the fusion protein BCR/ABL in transformed cells. The constitutively active tyrosine kinase BCR/ABL confers enhanced proliferation and survival on leukemic cells. READ MORE

  4. 4. Dysregulated mucosal immune responses in microscopic colitis patients

    Author : Sezin Günaltay; Elisabeth Hultgren-Hörnquist; Olof Hultgren; Nils Nyhlin; Allan Mowat; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microscopic colitis; collagenous colitis; lymphocytic colitis; TLR; chemokine; chemokine receptor; IL-37; TCR; Immunologi; Immunology; Biomedicin; Biomedicine;

    Abstract : Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC) is a common cause of chronic watery diarrhea. The diagnosis relies on typical histopathological changes observed upon microscopic examination. READ MORE

  5. 5. CD40L Gene Therapy for Solid Tumors

    Author : Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

    Abstract : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. READ MORE