Search for dissertations about: "Pheochromocytoma genetics"

Found 5 swedish dissertations containing the words Pheochromocytoma genetics.

2. 1. Molecular studies of endocrine tumors : Insights from genetics and epigenetics

   Author : Samuel Backman; Per Hellman; Peter Stålberg; Olov Norlén; Robert Bränström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumors; Carcinoid; Pheochromocytoma; Aldosterone; Cancer; MEN1; Multiple endocrine neoplasia; Medicinsk vetenskap; Medical Science;

   Abstract : Endocrine tumors may be benign or malignant and may occur in any of the hormone producing tissues. They share several biological characteristics, including a low mutation-burden, and may co-occur in several hereditary tumor syndromes. The aim of this thesis was to identify genetic and epigenetic aberrations in endocrine tumors. READ MORE

4. 2. Genetic Aspects of Endocrine Tumorigenesis : A Hunt for the Endocrine Neoplasia Gene

   Author : Alberto Delgado Verdugo; Peyman Björklund; gunnar westin; Per Hellman; Filip Farnebo; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exome sequencing; SDHAF2; epigenetics; methylation; methylation array; Sanger sequencing; pheochromocytoma; SI-NETs; carcinoid; oncology; endocrine surgery; parathyroid; Genetics; Genetik; Kirurgi; Surgery;

   Abstract : Endocrine tumors arise from endocrine glands. Most endocrine tumors are benign but malignant variants exist. Several endocrine neoplasms display loss of parts of chromosome 11 or 18, produce hormones and responds poorly to conventional chemotherapeutics. The multiple endocrine neoplasia syndromes are mainly confined to endocrine tumors. READ MORE

5. 3. Incidentally discovered adrenal tumours, adrenal metastases and pheochromocytomas - Clinical and epidemiological aspects

   Author : Andreas Muth; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incidental Findings; Adrenal incidentaloma; Adrenal Gland Neoplasms; Adrenalectomy; Follow-Up Studies; Quality of Life; Pheochromocytoma epidemiology; Pheochromocytoma genetics; Paraganglioma epidemiology; Paraganglioma genetics;

   Abstract : With increasing use of high resolution radiological imaging incidentally discovered adrenal tumours (adrenal incidentalomas, AI) have become a common clinical problem. The aim of work-up and follow-up of patients with AI is to detect malignant (primary or metastatic) and/or hormone-producing tumours. READ MORE

6. 4. Statistical assessment of genomic variability in tumours and bacterial communities

   Author : Anna Rehammar; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; somatic mutations; hierarchical Bayesian modelling; cancer genetics; high-throughput sequencing; metagenomics; personalised diagnostics;

   Abstract : Current high-throughput DNA sequencing technologies have the ability to generate large amounts of high-resolution genomic data. The high dimensionality in combination with the substantial levels of technical errors and biological variability typically present in the data make, however, the analysis challenging. READ MORE

7. 5. Genetic Alterations in Pheochromocytoma and Paraganglioma

   Author : Jenny Welander; Peter Söderkvist; Oliver Gimm; Mercedes Robledo; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pheochromocytoma; paraganglioma; genetics; sequencing; cancer; mutation;

   Abstract : Pheochromocytomas and paragangliomas are neuroendocrine tumors that arise from neural crest-derived cells of the adrenal medulla and the extra-adrenal paraganglia. They cause hypertension due to an abnormally high production of catecholamines (mainly adrenaline and noradrenaline), with symptoms including recurrent episodes of headache, palpitations and sweating, and an increased risk of cardiovascular disease. READ MORE