Search for dissertations about: "Phospholipase C Beta 3 gene PLCB3"

Found 2 swedish dissertations containing the words Phospholipase C Beta 3 gene PLCB3.

2. 1. Phospholipase C β3, and its role in endocrine tumorigenesis

   Author : Peter Stålberg; Uppsala universitet; []
   Keywords : Medical sciences; Phospholipase C beta 3; endocrine tumors; in situ hybridization; transfection; tumorsuppressor; differential expression; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : The Phospholipase C β3 (PLCB3) gene is located on chromosome 11q13, in the vicinity of theMultiple Endocrine Neoplasia type 1 (MEN1) suppressor gene. PLCB3 has been implicated inendocrine tumorigenesis based on findings of low expression in endocrine tumors, and the probableexistence of other suppressor genes located at 11q13. READ MORE

4. 2. Isolation and characterization of genes within the region for multiple endocrine neoplasia type 1 on chromosome 11q13

   Author : Jacob Lagercrantz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Multiple Endocrine Neoplasia type 1 MEN1 ; Chromosome 11q13; Phospholipase C Beta 3 gene PLCB3 ; Phospholipase C Beta 3 Neighbouring Gene PNG ; Vascular Endothelial Growth Factor VEGF ; VEGF Related Factor gene VRF .;

   Abstract : This thesis summarizes the investigations of three genes isolated from the locus for multiple endocrine neoplasia type 1 (MEN1) within the chromosomal region 11q13. As a common strategy for all three genes, the cDNA was sequenced, the genomic structure characterized, and the expression pattern analyzed by Northern blotting on human tissues and by in situ RNA hybridization on slides from rodent embryos. READ MORE