Search for dissertations about: "Photoaffinity labeling"

Found 2 swedish dissertations containing the words Photoaffinity labeling.

  2. 1. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Author : Tina Seifert; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Abstract : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. READ MORE

  4. 2. Adenosine A2A receptors : characterization, localization, G protein coupling and interactions with dopamine D2 receptors

    Author : Björn Kull; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine receptors; receptor-receptor interactions; G proteins; species differences;

    Abstract : Adenosine not only has a role in cellular energy metabolism but is recognized as an intercellular messenger with an important function in physiology and pathophysiology. It exerts its effects via a family of G protein coupled receptors of which four members have been cloned from several species: A, A2A, A2B and A3. READ MORE