Search for dissertations about: "Photoreceptor"

Showing result 16 - 20 of 49 swedish dissertations containing the word Photoreceptor.

  2. 16. Structural and functional alterations in the rat retina after long term exposure to two n-hexane metabolites

    Author : Birgitta Bäckström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : n-Hexane; 2; 5-hexanedione; 2; 5-hexanediol; immunohistochemical techniques; neurotoxicity; retinopathy; photoreceptors; light energy; electrophysiology; pupil;

    Abstract : Exposure to the two n-hexane metabolites, 2,5-hexanedione (2,5-HD) and 2,5-hexanediol (2,5-HDol) causes swellings in the distal part of long nerve axons. This phenomenon, centralperipheral distal axonopathy, was studied using an indirect immuno-peroxidase method with monoclonal antibodies to neurofilament protein. READ MORE

  4. 17. Models of Retinal Development and Disease

    Author : Minas Hellsand; Finn Hallböök; Emma Andersson; Department of Cell and Molecular Biology Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Developmental neurobiology; retinal organoids; retinoblastoma; MYCN; Stargardt disease; Bardet-Biedl syndrome; model systems;

    Abstract : For a model of a human disease to be valid and useful, it is important that key genotypic and phenotypic traits are shared between model system and human. The work in this thesis has been focused on generating new and characterizing spontaneous models of three genetic disorders affecting the retina: retinoblastoma, a childhood cancer with its origin in the fetal retina, Stargardt disease, a juvenile form of macular degeneration, and Bardet-Biedl syndrome, a pleiotropic ciliopathy featuring retinal degeneration. READ MORE

  5. 18. Experimental Neuroretinal Transplantation

    Author : Fredrik Ghosh; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transplant; Retinal degeneration; Retina; Rabbit; Neural development; Immunohistochemistry; MHC; Ultrastructure; Vitrectomy; Ophtalmology; Oftalmologi;

    Abstract : Embryonic full-thickness rabbit neuroretinal sheets were transplanted to the subretinal space of adult hosts. This was accomplished by using a new transplantation technique involving vitrectomy and retinotomy. The grafts were followed from 10 to 306 days after surgery, and were then examined by different histological techniques. READ MORE

  6. 19. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression

    Author : Hanzhao Zhang; Finn Hallböök; Johan Holmberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYCN; retinoblastoma; RNA sequencing; cancer; avian; E2F; carcinogenesis; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

    Abstract : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. READ MORE

  7. 20. Molecular Regulation of the Annual Growth Cycle in Populus Trees

    Author : Domenique André; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Adaptation to the change of seasons is essential for tree survival. Here I show that the phenology of hybrid aspen is regulated by three FLOWERING LOCUS T (FT) genes.FT1, FT2a and FT2b are the result of both a whole genome and a local duplication. READ MORE