Search for dissertations about: "Physics with specialization in Biophysics"

Showing result 11 - 15 of 16 swedish dissertations containing the words Physics with specialization in Biophysics.

  2. 11. Simulations of Biomolecular Fragmentation and Diffraction with Ultrafast X-ray Lasers

    Author : Christofer Östlin; Carl Caleman; Nicusor Timneanu; Helmut Grubmüller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; X-ray free-electron laser; X-ray imaging; Single particle imaging; Computer simulation; Radiation damage; Molecular dynamics; Diffraction theory; Coulomb explosion; Sample heterogeneity; Diffractive noise; XFEL; SPI; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Studies of biomolecules have recently seen substantial developments. New X-ray lasers allow for high-resolution imaging of protein crystals too small for conventional X-ray crystallography. Even structures of single particles have been determined at lower resolutions with these new sources. READ MORE

  4. 12. Towards Fast and Robust Algorithms in Flash X-ray single-particle Imaging

    Author : Jing Liu; Stefan Engblom; Filipe Maia; Janos Hajdu; Helmut Grubmüller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray Free Electron lasers XFELs ; 3D electron density determination; Machine learning; Image processing; High-performance computing; GPUs; Uncertainty quantification; X-ray single-particle Imaging; Flash X-ray single-particle diffraction Imaging FXI ; ; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Modern X-ray Free Electron Laser (XFEL) technology provides the possibility to acquire a large number of diffraction patterns from individual biological nano-particles, including proteins, viruses, and DNA. Ideally, the collected data frames are high-quality single-particle diffraction patterns. READ MORE

  5. 13. Ultrafast Structural and Electron Dynamics in Soft Matter Exposed to Intense X-ray Pulses

    Author : Olof Jönsson; Carl Caleman; Nicusor Timneanu; Olle Björneholm; Jörgen Larsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; X-ray free-electron laser; Serial Femtosecond Crystallography; Radiation Damage; Plasma Simulations; Ultrafast Lasers; X-ray Imaging; Diffraction Theory; Ultrafast Phenomena; Hit Detection; Plasma Emission Spectra; Serial Femtosecond Crystallography; Protein Structure; Protein Crystallography; Metalloprotein; Non-thermal Heating; Water; Ferredoxin; NLTE Simulation; XFEL; FEL; SFX; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Investigations of soft matter using ultrashort high intensity pulses have been made possible through the advent of X-ray free-electrons lasers. The last decade has seen the development of a new type of protein crystallography where femtosecond dynamics can be studied, and single particle imaging with atomic resolution is on the horizon. READ MORE

  6. 14. Gas-Phase Protein Structure Under the Computational Microscope : Hydration, Titration, and Temperature

    Author : Erik Marklund; David van der Spoel; Albert Heck; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; gas phase; proteins; micelles; proton transfer; Grothuss mechanism; kinetics; Physics; Fysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Although the native environment of the vast majority of proteins is a complex aqueous solution, like the interior of a cell, many analysis methods for assessing chemical and physical properties of biomolecules require the sample to be aerosolized; that is, transferred to the gas-phase. An important example is electrospray-ionization mass spectrometry, which can provide a wide range of information about e. READ MORE

  7. 15. Statistical processing of Flash X-ray Imaging of protein complexes

    Author : Alberto Pietrini; Carl Nettelblad; Johan Bielecki; Janos Hajdu; Flavio Capotondi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; X-ray; XFEL; single particle; hit-finder; statistical hit-finder; single protein; protein complex; RNA polymerase II; FEL; free-electron laser; FXI; Flash X-ray Imaging; CXI; CSPAD; x-ray imaging; COACS; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Abstract : Flash X-ray Imaging (FXI) at X-ray Free Electron Lasers (XFELs) is a promising technique that permits the investigation of the 3D structure of molecules without the need for crystallization, by diffracting on single individual sample particles.In the past few years, some success has been achieved by using FXI on quite large biological complexes (40 nm-1 μm in diameter size). READ MORE