Search for dissertations about: "Pituitary adenylate cyclase-activating polypeptide"
Showing result 1 - 5 of 12 swedish dissertations containing the words Pituitary adenylate cyclase-activating polypeptide.
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1. Pituitary adenylate cyclase activating polypeptide : Expression and neurotrophic activity in the rat brain
Abstract : Neurotrophic factors play an important role in regulating naturally occurring cell death during neurogenesis. In addition to classical neurotrophic factors, some neurotransmitters and neuropeptides have been shown to exhibit neurotrophic activities. READ MORE
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2. Aspects of aqueous humor dynamics : Studies in vivo and in vitro
Abstract : The purpose of the present investigation was to study the effects of PGF2α-l-isopropylester, some neuropeptides, and pharmacological agents on aqueous humor dynamics and intraocular pressure (IOP) in vivo and on adenylate cyclase activity in the nonpigmented ciliary epithelium (NPE) in vitro.Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) caused a dose-dependent increase in cAMP formation, indicating that the NPE contains receptors for PACAP and VIP coupled to adenylate cyclase activation. READ MORE
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3. Regulation of Islet Function by the Neuropeptide PACAP
Abstract : It is known that parasympathetic, sympathetic and sensory nerves innervate the islets and that these nerves harbor both classical neurotransmitters and neuropeptides. However, the neural influence on islet hormone release is complex and not yet fully understood A recently discovered pancreatic neuropeptide is pituitary adenylate cyclase-activating polypeptide (PACAP). READ MORE
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4. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord
Abstract : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). READ MORE
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5. The neuropeptides GRP and PACAP and the function of the endocrine pancreas - A study on receptor deficient mice
Abstract : The parasympathetic nerves are important for the regulation of insulin secretion, in particular after meal intake. Apart from acetylcholine, several neuropeptides can be found in the parasympathetic nerves innervating the islets of Langerhans, including gastrin-releasing peptide (GRP) and pituitary adenylate cyclase activating polypeptide (PACAP). READ MORE