Search for dissertations about: "Plasmacytoid dendritic cell"
Showing result 6 - 10 of 34 swedish dissertations containing the words Plasmacytoid dendritic cell.
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6. Regulation of the germinal center response by T follicular helper cells and type I interferons
Abstract : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. READ MORE
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7. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases
Abstract : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. READ MORE
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8. Human cytomegalovirus and dendritic cell interaction : role in immunosupression and autoimmunity
Abstract : Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in patients with an impaired immune system. The virus itself can cause transitory but significant immunosuppression in immunocompetent as well as immunocompromised infected individuals. READ MORE
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9. Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses
Abstract : Allergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. READ MORE
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10. Regulation of Type I Interferon Production in Plasmacytoid Dendritic Cells : Effect of Genetic Factors and Interactions with NK Cells and B Cells
Abstract : The type I interferon (IFN) system plays a central role in the etiopathogenesis of many autoimmune diseases, e.g. systemic lupus erythematosus (SLE). Activation of the type I IFN system in SLE is promoted by endogenous nucleic acid-containing immune complexes (ICs) which stimulate plasmacytoid dendritic cells (pDCs). READ MORE