Search for dissertations about: "Platelet derived growth factor B-chain"

Found 5 swedish dissertations containing the words Platelet derived growth factor B-chain.

  2. 1. Studies of platelet-derived growth factor (PDGF) B-chain and PDGF ß-receptors in rheumatoid arthritis and wound healing : characterization of the PDGF B-chain and PDGF ß-receptor expression

    Author : Christina Reuterdahl; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. Platelet-derived growth factor-induced signal transduction

    Author : Sigrídur Valgeirsdóttir; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells, elicits its effects by binding to cell surface tyrosine kinase receptors, denoted α- and β-receptors. This thesis describes the mechanism of interaction between stimulated PDGF receptors and various intracellular molecules. READ MORE

  5. 3. Actions and interactions of insulin-like growth factor-I and insulin in vascular smooth muscle

    Author : Karin E. Bornfeldt; Ulf Smith; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Insulin-like growth factor-I (IGF-I) is a polypeptide with structural and biological similarities with insulin, and the receptors for IGF-I and insulin are homologous. The present investigation was devoted to the actions and interactions of IGF-I and insulin in vascular smooth muscle. READ MORE

  6. 4. The role of PDGFB in dermatofibrosarcoma protuberans and giant cell fibroblastoma

    Author : Kevin P O'Brien; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dermatofibrosarcoma protuberans; giant cell fibroblastoma; translocation; FISH; translocation breakpoint; fusion gene; oncogene; Platelet derived growth factor B-chain; collagen type I alpha 1; tumor formation; autocrine stimulation;

    Abstract : Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are rare invasive tumors of the dermis. GCF is considered the juvenile form of DFSP. Both DFSP and GCF are characterized by the presence of chromosomal aberrations involving chromosomes 17 and 22. READ MORE

  7. 5. Paracrine and autocrine functions of PDGF in malignant disease

    Author : Tobias Sjöblom; Lars Holmgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cellbiologi; Cell biology; Cellbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Growth factors and their receptors are frequently activated by mutations in human cancer. Platelet-derived growth factor (PDGF)-B and its tyrosine kinase receptor, the PDGF β-receptor, have been implicated in autocrine transformation as well as paracrine stimulation of tumor growth. READ MORE