Search for dissertations about: "Polycomb group"

Showing result 1 - 5 of 14 swedish dissertations containing the words Polycomb group.

2. 1. Suppressor of zeste 12, a Polycomb group gene in Drosophila melanogaster; one piece in the epigenetic puzzle

   Author : Anna Birve; Anssi Saura; Allen Shearn; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Drosophila melanogaster; epigenetic; homeotic genes; Polycomb group; PRE; heterochromatin; Suppressor of zeste 12; chromatin silencing; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

   Abstract : In multicellular organisms all cells in one individual have an identical genotype, and yet their bodies consist of many and very different tissues and thus many different cell types. Somehow there must be a difference in how genes are interpreted. So, there must be signals that tell the genes when and where to be active and inactive, respectively. READ MORE

4. 2. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

   Author : Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

   Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE

5. 3. Expression and function of Suppressor of zeste 12 in Drosophila melanogaster

   Author : Sa Chen; Åsa Rasmuson-Lestander; Jan Larsson; Mattias Mannervik; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; histone; polycomb; Drosophila; Suppressor of zeste 12; Genetics; Genetik; genetik; Genetics;

   Abstract : The development of animals and plants needs a higher order of regulation of gene expression to maintain proper cell state. The mechanisms that control what, when and where a gene should (or should not) be expressed are essential for correct organism development. READ MORE

6. 4. Regulation of gene expression in fruit flies : how does it start, and will it be remembered?

   Author : Aman Zare; Per Stenberg; Yuri B. Schwartz; Åsa Rasmuson-Lestander; Guillaume Filion; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; epigenetics; transcription; gene regulation; transcription maintenance; CBP; polymerase pausing; Polycomb group proteins; transgenerational inheritance of transcriptional response; gut microbiome; molekylärbiologi; Molecular Biology;

   Abstract : One of the most distinctive features of eukaryotic chromosomes is the bundling of DNA together with functionally associated RNA and proteins in chromatin. This allows huge amounts of DNA to be packed inside the very tiny space of the nucleus, and alterations in the structure of chromatin enable access to the DNA for transcription (“reading” genes by production of RNA copies). READ MORE

7. 5. The interplay of transcription and chromatin regulation during embryonic development

   Author : George Hunt; Mattias Mannervik; Eileen Furlong; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription; chromatin; chromatin-modifiers; p300 CBP; Polycomb repression; promoter proximal Pol II pausing; molekylär biovetenskap; Molecular Bioscience;

   Abstract : A fascinating aspect of multicellular development is the production of diverse cell types from an identical DNA genome, which depends on the ability to express different complements of genes across space and time. This thesis tries to address how the genome, within the chromatin structure that envelops it, is regulated to direct this complex process. READ MORE