Search for dissertations about: "Post transcriptional regulation"

Showing result 11 - 15 of 144 swedish dissertations containing the words Post transcriptional regulation.

  2. 11. Mechanistic characterization of post-transcriptional gene silencing

    Author : Cecilia Dahlgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : With the ongoing task of identifying and characterizing genes in the human genome, there is a great demand for tools to study these genes. Today, reverse genetics is the most effective way to explore gene function. This involves suppression of the gene of interest by a set of manipulation techniques. READ MORE

  4. 12. Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex

    Author : Cecilia Boreström; Göteborgs universitet; []
    Keywords : Epstein-Barr virus; EBNA1; NF-Y; Sp1; Oct-2; Bright; E2F1; transcriptional regulation; Cp; oriP;

    Abstract : Epstein-Barr Virus (EBV) is an exclusively human, lymphotropic herpes virus that infects more than 90% of the population worldwide. Primary infection usually occurs during the early years of life and does not result in any recognized disease. READ MORE

  5. 13. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

    Author : Azra Alajbegovic; Molekylär kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

    Abstract : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. READ MORE

  6. 14. Actin and myosin in transcriptional and post-transcriptional control of gene expression

    Author : Ales Obrdlik; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Actin plays a key role in basal gene regulation. In the past decade actin has been found to be a component of chromatin remodeling complexes, ribonucleoprotein particles and to associate with all eukaryotic RNA polymerases. READ MORE

  7. 15. Beyond transcription : a post-transcriptional role of 3D chromatin crosstalk in oncogene regulation

    Author : Johanna Vestlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis explores how stochastic chromatin fibre interactions, chromatin organization in the 3D nuclear architecture, and environmental signals collaborate to regulate MYC oncogene expression in human colon cancer cells. In Paper I, we employ the ultra-sensitive Nodewalk technique to uncover the dynamic and stochastic nature of chromatin networks impinging on MYC. READ MORE