Search for dissertations about: "Post tuberculosis"

Showing result 1 - 5 of 13 swedish dissertations containing the words Post tuberculosis.

  2. 1. Helminths and immunity against tuberculosis

    Author : Daniel Elias; Karolinska Institutet; Karolinska Institutet; []
    Keywords : tuberculosis; BCG; helminths; immunomodulation; vaccination;

    Abstract : The efficacy of Bacille Calmette Guerin (BCG) is low and incidence of tuberculosis (TB) is high in those areas where helminths are endemic. Protection against tuberculosis requires strong cell mediated immunity while chronic helminth infections induce responses characterized by dominant Th2 responses as well as up-regulated regulatory T cell activity. READ MORE

  4. 2. Structure-Based Virtual Screening : New Methods and Applications in Infectious Diseases

    Author : Micael Jacobsson; Anders Karlén; Mats Kihlén; Antti Poso; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : drug discovery; docking; scoring; virtual screening; malaria; tuberculosis; Pharmaceutical chemistry; Läkemedelskemi;

    Abstract : A drug discovery project typically starts with a pharmacological hypothesis: that the modulation of a specific molecular biological mechanism would be beneficial in the treatment of the targeted disease. In a small-molecule project, the next step is to identify hits, i.e. molecules that can effect this modulation. READ MORE

  5. 3. Immunological aspects of latent tuberculosis infection during pregnancy

    Author : Fregenet Tesfaye Tegegn; Klinisk infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon-γ; immune mediators; latent tuberculosis infection; Mtb-antigen reactivity; pregnancy; QuantiFERON-TB Gold Plus;

    Abstract : Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. READ MORE

  6. 4. Clinical and prophylactic studies of human tuberculosis in a low-endemic setting

    Author : Maria Norrby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sweden is a low burden country for tuberculosis (TB). New cases occur mainly among immigrants from countries with a higher TB prevalence. Most persons infected with TB (latent TB) will not develop disease (active TB). Prolonged treatment is necessary and can cause severe adverse drug reactions. READ MORE

  7. 5. Improving treatment outcomes for patients with pulmonary tuberculosis in Tanzania : host and pathogen factors

    Author : Tumaini Joseph Nagu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tuberculosis (TB) causes more than 1.2 million deaths each year globally. Yet, survivors of tuberculosis are left with long term sequelae of chronic inflammatory responses with consequent reduced quality of life. READ MORE