Search for dissertations about: "Post-Translational"

Showing result 11 - 15 of 206 swedish dissertations containing the word Post-Translational.

  2. 11. Post-translational modifications in mammary gland development and mammary tumor progression

    Author : Ting Zhuang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is one of the most common cancers in women. Estrogen receptor α (ERα) signaling and p53 signaling have important roles in breast cancer progression. Therefore, post-translational modifications of ERα and p53 play critical roles in breast cancer. READ MORE

  4. 12. From Physicochemical Features to Interdependency Networks : A Monte Carlo Approach to Modeling HIV-1 Resistome and Post-translational Modifications

    Author : Marcin Kierczak; Jan Komorowski; Anna Tramontano; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; HIV-1; resistome analysis; drug resistance; predicting PTMs; molecular interdependency networks; MCFS-ID; feature selection; interactome; machine-learning; rough sets; Bioinformatics; Bioinformatik; Computer Science; datavetenskap; Biology; with specialization in structural biology; biologi; med inriktning mot strukturbiologi;

    Abstract : The availability of new technologies supplied life scientists with large amounts of experimental data. The data sets are large not only in terms of the number of observations, but also in terms of the number of recorded features. READ MORE

  5. 13. Post-translational modification of estrogen receptor alpha and p53 in breast cancer cells

    Author : Jian Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen receptor α (ERα/ESR1) and tumor protein p53 (p53/TP53) signaling are aberrant and play important roles in breast cancer pathogenesis and evolution. ERα is highly expressed in the majority of breast cancers and is an important contributor to the development of these tumors. READ MORE

  6. 14. Expression and post-translational modification of purple acid phosphatase in insect and mammalian cells

    Author : Yunling Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Purple acid phosphatase (PAP) is an acidic metallohydrolase that contain a binuclear iron center in its active site. In mammals, this enzyme is also referred to as tartrate-resistant acid phosphatase (TRAPs), uteroferrin or type 5 acid phosphatase. READ MORE

  7. 15. Antimicrobial peptides in innate immunity : interactions with antibiotics and effects of post-translational modifications

    Author : Salma Al Adwani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cationic antimicrobial peptides (AMPs) are important innate immunity factors contributing to the clearance of invading pathogens and immunomodulating immune responses. In this thesis, the focus is on AMPs of the cathelicidin family, i.e. the human LL-37 and the canine K9CATH. READ MORE