Search for dissertations about: "Poul Henning Jensen"

Found 2 swedish dissertations containing the words Poul Henning Jensen.

  2. 1. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

    Author : Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

    Abstract : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). READ MORE

  4. 2. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43

    Author : Christopher Sackmann; Martin Hallbeck; Emelie Severinsson; Poul Henning Jensen; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α-synuclein; amyloid-β; TDP-43; cell to cell transmission;

    Abstract : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. READ MORE