Search for dissertations about: "Prdm2"

Found 2 swedish dissertations containing the word Prdm2.

  1. 1. Overlapping Neural Substrates of Alcohol- and Anxiety-Related Behavior in the Rat

    Author : Riccardo Barchiesi; Estelle Barbier; Markus Heilig; Annika Thorsell; Andrew Holmes; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcohol use disorder; Anxiety disorder; Behavior; Rat; Prelimbic cortex; Amygdala; Basolateral amygdala; Stress; Epigenetics; Syt1; Prdm2; Avp; Conditioned fear; Social defeat stress; Witness stress; Susceptibility; Resilience;

    Abstract : Alcohol use is a leading cause of death and disease worldwide. A large part of this disease burden is associated with alcohol use disorder (AUD), a diagnostic category characterized by excessive use in spite of negative consequences ("compulsive use"), a loss of control over intake, and choice of alcohol over natural rewards. READ MORE

  2. 2. Targeting allelic loss in colorectal cancer

    Author : Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Abstract : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. READ MORE