Search for dissertations about: "Preclinical study"

Showing result 11 - 15 of 155 swedish dissertations containing the words Preclinical study.

2. 11. A preclinical therapy model for childhood neuroectodermal tumours

   Author : Isabell Hultman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Childhood cancers show fundamental differences to most common adult solid tumours in their cancer-causing genetics, cell biology and their local tissue microenvironment. Effective treatments will be attainable when the molecular events that are specific to childhood tumourigenesis are better understood. READ MORE

4. 12. Preclinical imaging of prostate cancer using radiolabeled antibodies

   Author : Susan Evans Axelsson; Malmö Urologisk cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Target-specific molecular imaging with radiolabeled antibodies has experienced a rapid growth over the past 20 years, and is now an essential tool to provide information on disease presence and extent. Despite all efforts to detect and control prostate cancer at an early stage, a number of men are still progressing to develop incurable metastatic disease. READ MORE

5. 13. Cognitive functioning in the preclinical stages of Alzheimer's disease and vascular dementia

   Author : Sari Jones; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Cognition; preclinical; Alzheimer s disease; vascular dementia; neuropsychology;

   Abstract : This doctoral thesis concerns cognitive functioning in the preclinical stages of Alzheimer's disease (AD) and vascular dementia (VaD). It is based on five empirical studies using data from the Kungsholmen Project, a longitudinal population-based study of aging and dementia targeting persons 75 years and older, living in the Kungsholmen District in Stockholm, Sweden. READ MORE

6. 14. Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease

   Author : Erik Stomrud; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; EEG; phosphorylated tau protein; amyloid beta protein; tau protein; cerebrospinal fluid; biomarkers; preclinical Alzheimer s disease; Alzheimer s disease; MCI; dementia; SPECT; memory; cognition; early diagnosis; control groups;

   Abstract : Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. READ MORE

7. 15. Bombesin Antagonists for Targeting Gastrin-Releasing Peptide Receptor-Positive Tumors : Design, Synthesis, Preclinical Evaluation and Optimization of Imaging Agents

   Author : Zohreh Varasteh; Anna Orlova; Roger Schibli; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bombesin; Gastrin-releasing peptide receptor GRPR ; Antagonist; Radionuclide molecular imaging;

   Abstract : This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers for the detection of gastrin-releasing peptide receptor (GRPR)-expressing tumors. The work is divided into three distinct parts: (1) the development of bombesin (BN) antagonist (RM26)-based imaging radiotracers for the detection of GRPR-expressing tumors using different positron emission tomography (PET) and single photon emission computed tomography (SPECT) radionuclides (68Ga, 18F and 111In), (2) the establishment of a method to monitor the ligand-G protein-coupled receptor (GPCR) interaction in real time without requiring purification and stabilization of the receptors, and (3) the evaluation of radiopeptide structure-related factors (length of mini-PEG linker and composition of chelator for metal labeling) affecting the in vitro and in vivo characteristics of RM26-based tracers. READ MORE