Search for dissertations about: "Presynaptic Inhibition"

Showing result 21 - 25 of 26 swedish dissertations containing the words Presynaptic Inhibition.

  2. 21. Noradrenergic augmentation strategies in the pharmacological treatment of depression and schizophrenia : an experimental study

    Author : Love Linnér; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The pharmacological treatment of depression and schizophrenia, two major psychiatric disorders, is largely based on modulation of central monoaminergic neurotransmission. However, currently available pharmacological treatment alternatives possess a relatively modest clinical efficacy, making them less than optimal. READ MORE

  4. 22. Effects of acute alcohol exposure on glutamate neurotransmission in adolescents and adults : a preclinical study

    Author : Devesh Mishra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The age at which an individual first uses alcohol is a powerful predictor of alcohol dependence later in life. Brain development and maturation continues during adolescence until adulthood in humans. READ MORE

  5. 23. Anatomical and functional characterization of serotonergic neurocircuitry

    Author : Iskra Pollak Dorocic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The serotonin system arises from a small collection of brainstem structures called the raphe nuclei and innervates much of the central nervous system. A relatively small number of serotonin neurons modulate a wide variety of functions, from the basic such as homeostatic regulation of sleep and feeding to more complex roles in mood, motivation and emotion. READ MORE

  6. 24. Alzheimer's disease : uncovering mechanisms for amyloid precursor protein processing and trafficking

    Author : Saket Milind Nigam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by impairment of memory and, eventually, by disturbances in cognitive abilities. Brain regions crucial for learning and memory exhibit atrophy, but the underlying mechanisms for neurodegeneration continues to be point of debate. READ MORE

  7. 25. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Author : Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Abstract : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. READ MORE