Search for dissertations about: "Primary sensory neurons"

Showing result 1 - 5 of 35 swedish dissertations containing the words Primary sensory neurons.

2. 1. Distribution and function of TRP ion channels in primary sensory neurons

   Author : Helena Sturesson; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; histokemi; cytokemi; vävnadskultur; Neurology; neuropsychology; neurophysiology; Neurologi; tissue culture; histochemistry; cytochemistry; Histology; Skin; Immunohistochemistry; Cannabinoid receptor 1 CB1 ; Pain; Primary sensory neurons; TRP ion channels; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Histologi;

   Abstract : It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. READ MORE

4. 2. Neuropeptides, sensory neurons and pain modulation

   Author : Pablo R Brumovsky; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In the present thesis work we have analyzed the expression, regulation and function of two neuropeptides: galanin and neuropeptide tyrosine (NPY). Their associated receptors, galanin receptor-1 and -2 (GaIR1, -R2) and NPY Y1- and Y2R, were also studied. READ MORE

5. 3. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence

   Author : Yu Ming; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Aging; dorsal root ganglion; spinal cord; muscle; neurotrophins; GFRalpha; Ret; FGF-2; gp 130; CNTF; LIF; IL-6; receptors; protein; mRNA; glia; axon dystrophy; demyelination.;

   Abstract : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. READ MORE

6. 4. Structure and function of trigeminal primary sensory neurons after peripheral nerve injury

   Author : Ulf Bongenhielm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ankyrinG; chronic constriction injury; electron microscopy; electrophysiology; hyperexcitability; immunocytochemistry; inferior alveolar nerve; in situ hybridisation; nerve injury; neuroma; SNS PN3; sodium channel; trigeminal ganglion;

   Abstract : Iatrogenic injuries to branches of the trigeminal nerve are common during surgical procedures in the jaws and teeth, and as the repercussion of facial fractures or certain pathologies. A portion of these patients are left with disturbed sensory functions, and some with unpleasant abnormal sensations, including pain. READ MORE

7. 5. The effects of neurotrophic substances on primary sensory neurons following peripheral nerve injury

   Author : Petri Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : DRG; dorsal horn; NGF; BDNF; NT-3; substance P; calcitonin gene-related peptide; fluoride-resistant acid phosphatase; carbonic anhydrase; microglia; astroglia;

   Abstract : Sensory impulses from the periphery is transmitted by primary sensory neurons located in dorsal root and cranial nerve ganglia. The primary sensory neurons are phenotypically diverse with regard to their expression of various chemical components. READ MORE