Search for dissertations about: "Proenkephalin"

Showing result 1 - 5 of 6 swedish dissertations containing the word Proenkephalin.

  2. 1. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Author : Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Keywords : Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE

  4. 2. Isolation and characterization of lipid-associated and neurosecretory polypeptides

    Author : Margareta Stark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lipid-interacting proteins play important roles in all living organisms. This thesis focuses on isolation and characterization of an enzyme in the triacylglycerol biosynthesis (phosphatidic acid phosphatase, PAP), hydrophobic polypeptides in bile, and polypeptides in cerebrospinal fluid. READ MORE

  5. 3. The Impact of Drugs of Abuse on the Neuroproteome : Application of Immunoblotting and LC-MS-based Proteomics

    Author : Uwe Rossbach; Pierre Le Grevès; Fred Nyberg; Matthias Hallberg; Jan Kehr; Uppsala universitet; []
    Keywords : ;

    Abstract : Qualitative and quantitative analysis of proteins can be based either on immunological or on mass spectrometry-utilizing methods. In this thesis, different approaches of protein analysis were applied to elucidate the impact of drugs of abuse on the rat brain. Androgens have been reported to affect mood, anxiety and memory function. READ MORE

  6. 4. Sepsis - an ED perspective. Sepsis Alert & Biomarkers

    Author : Mari Rosenqvist; Kardiovaskulär forskning - hypertoni; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; Emergency Department; biomarkers; MR-proADM; penKid; triage; Sepsis Alert; implementation;

    Abstract : Background: Sepsis, the life-threatening organ dysfunction due to dysregulated host response to an infection, is a medical emergency. Early diagnosis and treatment are important factors to prevent mortality and morbidity. However, sepsis can be diffuse and difficult to interpret. READ MORE

  7. 5. Neurobiological effects of early life cannabis exposure in relation to the gateway hypothesis

    Author : Maria Ellgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of Cannabis sativa preparations, such as hashish and marijuana, is wide-spread among young people, including pregnant women. Despite this concern, the consequences of cannabis exposure on the brain during periods of active brain development, such as the prenatal phase and adolescence, is not well known. READ MORE