Search for dissertations about: "Proguanil"
Showing result 1 - 5 of 9 swedish dissertations containing the word Proguanil.
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1. Drug repositioning in chemoprevention of colorectal cancer
Abstract : BackgroundColorectal cancer (CRC) ranks as the third most frequently occurring cancer and the second leading cause of cancer-related deaths worldwide. In response to the high demand for an effective prevention strategy, chemoprevention, using medications to block the pathogenetic pathways of disease, might be an attractive strategy to offer a more effective option at a low cost. READ MORE
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2. Pharmacokinetics and dynamics of atovaquone and proguanil (Malarone®)
Abstract : Malarone® is a fixed dose combination of atovaquone and proguanil and is mainly used for prophylaxis against P. falciparum malaria as an alternative to Lariamo® or chloroquine+proguanil. READ MORE
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3. Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids
Abstract : The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. READ MORE
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4. Development of Analytical Methods for Measurement of Drugs against Malaria in Plasma and Whole Blood
Abstract : The aim of this thesis was to develop analytical methods for measuring drugs in blood and/or plasma. Solid phase extraction was used for the enrichment and purification of the drugs from the sample matrix. READ MORE
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5. CYP2C19 catalyzed drug metabolism in different populations
Abstract : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. READ MORE