Search for dissertations about: "Prohapten"
Found 2 swedish dissertations containing the word Prohapten.
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1. Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships
Abstract : Chemicals in our environment with which we have repeated skin contact can cause skin sensitisation (contact allergy). To trigger an immune response a compound (hapten) must be able to penetrate the skin, where it needs to be reactive enough to bind to proteins and form immunogenic complexes that are recognised as foreign. READ MORE
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2. Isothiocynates as skin sensitizers. Bioactivation and distribution in skin and draining lymph nodes
Abstract : Development of contact dermatitis can be caused by electrophilic compounds (haptens) or prohaptens that come into contact with the skin. A prohapten is a compound seemingly harmless at first sight that can be transformed into reactive metabolites by metabolizing enzymes in the skin to become a hapten. READ MORE