Search for dissertations about: "Proinsulin C-peptide"
Showing result 1 - 5 of 23 swedish dissertations containing the words Proinsulin C-peptide.
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1. Molecular aspects of proinsulin C-peptide interactions
Abstract : Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (C-peptide), which are released into the circulation. READ MORE
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2. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide
Abstract : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. READ MORE
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3. Proinsulin C-peptide : membrane interactions and intracellular signaling
Abstract : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. READ MORE
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4. Intracellular and peptide interactions of C-peptide
Abstract : Proinsulin C-peptide is depleted together with insulin in type I diabetic patients. The supplement of insulin to these patients is necessary for their survival, but it is also likely that the loss of C-peptide may contribute to both short- and long-term complications. In this thesis, molecular effects of C-peptide have been investigated. READ MORE
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5. Embryonic Stem Cells: Differentiation into Insulin Producing Cells and Elimination of Damaged Proteins
Abstract : This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. READ MORE