Search for dissertations about: "Promoter activity"

Showing result 1 - 5 of 331 swedish dissertations containing the words Promoter activity.

2. 1. TARP Promoter-Based Prostate Cancer Gene Therapy : From Development to Application

   Author : Wing-Shing Cheng; Magnus Essand; Thomas H. Tötterman; Cecilia Lundberg; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genetic engineering; TARP; PPT; TSTA; promoter; gene regulation; prostate specificity; hormone- independent; adenovirus; prostate cancer; gene therapy; conditionally replicating adenovirus; Genteknik; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik;

   Abstract : Prostate cancer is one leading cause of cancer-related death among men in Western countries. The standard therapies for localized prostate cancer include radical prostatectomy and radiation therapy. Such measures are relatively effective in the short term, but many patients ultimately relapse. READ MORE

4. 2. Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns

   Author : Helén Brogren; Göteborgs universitet; []
   Keywords : PAI-1; platelets; plasma; fibrinolysis; synthesis; polymorphism; glycosylation; activity; platelet mRNA;

   Abstract : Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present in high concentrations in platelets and also in low concentrations in plasma, but the source of plasma PAI-1 is not known. READ MORE

5. 3. Functional Studies on the PDGFR α gene promoter and effects of autocrine PDGF-A stimulation in vivo

   Author : Xiao-Qun Zhang; Hubert Schorle; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Autorcrine PDGF; promoter; PDGFRA; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : Platelet-derived growth factor receptor α (PDGFRα) plays an important role during embryogenesis. After implantation, the patterns of expression of Pdgfrα and its ligand Pdgf-A undergo an "autocrine-paracrine transition", in that Pdgf-A becomes expressed in the ectoderm and epithelia, while Pdgfrα is expressed in the adjacent mesenchymal tissue. READ MORE

6. 4. Studies of immunoglobulin light chains in rainbow trout (Oncorhynchus mykiss): new insight into the evolution of immunoglobulin genes

   Author : Sirje Timmusk; Greg Warr; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin genes; gene organization; evolution; comparative immunology; promoter; rainbow trout Oncorhynchus mykiss ; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylär immunologi; Molecular Immunology;

   Abstract : In this thesis, the structure and the expression of immunoglobulin (Ig) light chain genes were studied in rainbow trout and including an evolutionary perspective. A novel Ig light chain locus (IgL2) was identified and characterized. READ MORE

7. 5. Adenovirus-mediated CD40 Ligand Immunotherapy of Prostate and Bladder Cancer

   Author : Helena Dzojic; Magnus Essand; Thomas H Tötterman; Aristides Eliopoulos; Uppsala universitet; []
   Keywords : Medicine; immunotherapy; gene therapy; prostate cancer; bladder cancer; adenoviral vector; CD40 ligand; promoter; PPT; TSTA; depsipeptide FK228; TRAMP-C2; Medicin;

   Abstract : Cancer immunotherapy aims at reversing the immunosuppressive tumor environment and enhancing anti-tumor immunity. This thesis comprises studies on murine models for prostate (TRAMP-C2) and bladder (MB49) cancer with the aim to explore if the introduction of an adenoviral vector expressing CD40 ligand (AdCD40L) can induce anti-tumor immune responses. READ MORE