Search for dissertations about: "Proportional odds model"

Showing result 1 - 5 of 16 swedish dissertations containing the words Proportional odds model.

  2. 1. Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis

    Author : Maria C. Kjellsson; Mats O. Karlsson; Siv Jönsson; Gordon Graham; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacodynamics; Categorical data; Markov model; Modelling; NONMEM; NLMIXED; Laplace; Gaussian quadrature; Back-Step Method; Proportional odds model; Differential odds model;

    Abstract : Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. READ MORE

  4. 2. Models for Ordered Categorical Pharmacodynamic Data

    Author : Per-Henrik Zingmark; Mats O Karlsson; E. Niclas Jonsson; France Mentré; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacodynamic; Modelling; Categorical data; NONMEM; Proportional odds model; Markov model; Differential drug effect model; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE

  5. 3. Generalized survival models as a tool for medical research

    Author : Xingrong Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In medical research, many studies with the time-to-event outcomes investigate the effect of an exposure (or treatment) on patients’ survival. For the analysis of time-to-event or survival data, model-based approaches have been commonly applied. READ MORE

  6. 4. Screening for Cardiovascular Risk and Diabetes in Primary Health Care : The Söderåkra Risk Factor Screening Study

    Author : Ulla Petersson; Peter Nilsson; Carl Johan Östgren; Lars Brudin; Lars Weinehall; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Background: Cardiovascular disease (CVD) has been the predominant cause of morbidity and mortality for many decades in Sweden. Preventive work in primary health care through individual approach and community-based programmes has shown some success. READ MORE

  7. 5. Optimism and survivorship after esophageal cancer surgery

    Author : Yangjun Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dispositional optimism is a personality trait that represents generally favorable expectations about the future. The main aim of this thesis was to examine whether higher dispositional optimism was related to better subjectively reported outcomes and better objectively measured outcomes. READ MORE