Search for dissertations about: "Proteasome activation"

Showing result 1 - 5 of 55 swedish dissertations containing the words Proteasome activation.

  2. 1. Functional analysis of the proteasome in eukaryotic organisms

    Author : Marianthi Sakellari; Efstathios S. Gonos; Allan Sirsjö; Richard G. A. Faragher; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteasome; Proteasome activation; Protein synthesis inhibition; Hsp70; Hsp90; Proteostasis; Aging; Alzheimer’s disease; Caenorhabditis elegans; Lifespan extension; SKN-1;

    Abstract : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. READ MORE

  4. 2. Investigating the activation and regulation of the proteasome : an essential proteolytic complex

    Author : Patrick Masson; Patrick Young; Marcus Groettrup; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Proteasome; PA28gamma; Transcriptional regulation; Drosophila; 26S; Molecular biology; Molekylärbiologi;

    Abstract : The proteasome is a major non-lysosomal proteolytic complex present in eukaryotic cells and has a central role in regulating many protein levels. The complex has been shown to participate in various intracellular pathways including cell cycle regulation or quality control of newly synthesized proteins and many other key pathways. READ MORE

  5. 3. Tripeptidyl-Peptidase II : Structure, Function and Gene Regulation

    Author : Ann-Christin Lindås; Birgitta Tomkinson; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Keywords : Biochemistry; gene regulation; protein expression; enzyme kinetics; tripeptidyl-peptidase II; proteasome; intracellular protein degradation; exopeptidase; Biokemi;

    Abstract : The protein degradation process is of vital importance for the cell to maintain cellular functions. An important enzyme in this process is the multimeric tripeptidyl-peptidase II (TPP II). It removes tripeptides from a free N-terminus of the substrates. READ MORE

  6. 4. Protein Quality Control at the Inner Nuclear Membrane – The Asi complex in Saccharomyces cerevisiae

    Author : Marina Pantazopoulou; Per Ljungdahl; Jaspersen Sue; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; nuclear envelope; nuclear quality control NQC ; ubiquitin; proteasome; inner nuclear membrane-associated degradation INMAD ; Cell Biology; cellbiologi;

    Abstract : The nuclear envelope is a barrier comprised of outer and inner membranes that separate the cytoplasm from the nucleoplasm. The outer (ONM) and inner (INM) membranes have different physical characteristics and protein compositions. READ MORE

  7. 5. Pancreatic Cancer. Experimental and Clinical Studies

    Author : David Ljungman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic neoplasms; Proteasome inhibitors; Apoptosis; Intracellular signaling peptides and proteins; Epidermal growth factor receptor; Pancreaticoduodenectomy; Cost and cost analysis; Quality-adjusted life years; Copy number variations; Comparative genomic hybridization;

    Abstract : Background: Pancreatic cancer is one of the most lethal of known cancers and the only treatment with possibility of cure is surgery. The costs associated with treatment of pancreatic cancer are reputably high, both in terms of morbidity and financially. READ MORE