Search for dissertations about: "Protein Model Quality Assessment"
Showing result 6 - 10 of 15 swedish dissertations containing the words Protein Model Quality Assessment.
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6. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Abstract : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. READ MORE
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7. Structured Learning for Structural Bioinformatics : Applications of Deep Learning to Protein Structure Prediction
Abstract : Proteins are the basic molecular machines of the cell, performing a broad range of tasks, from structural support to catalysisof chemical reactions. Their function is determined by their 3D structure, which in turn is dictated by the order of their components, the amino acids. READ MORE
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8. Reversible modifications of chloroplast proteins and assessment of their functions
Abstract : Oxygenic photosynthesis is the process of solar energy conversion into chemical energy in the form of carbohydrates. This event is carried out by plants, algae and cyanobacteria and represents the starting point of the food chain in which most organisms are fed. READ MORE
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9. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals
Abstract : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. READ MORE
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10. Analysis of noncovalent and covalent protein-ligand complexes by electrospray ionisation mass spectrometry
Abstract : In this thesis, the application of electrospray ionisation mass spectrometry (ESI-MS) to the analysis of intact proteins is demonstrated. In papers I and II, the use of ESI-MS for the analysis of noncovalent protein-ligand complexes were discussed. READ MORE